Oxaprozin (Daypro): Basics, Side Effects & Reviews
Oxaprozin (Daypro)

Oxaprozin (Daypro)

Basics, Side Effects, Reviews & More

Oxaprozin (Daypro) works well to relieve symptoms of arthritis such as joint pain, swelling, and stiffness in both adults and children, but can cause mild skin reactions when exposed to sunlight.






Not a controlled medication


Lower-cost generic available


Prescription only

Reviewed by:

ThienLy Neal, PharmD

Allison Barnes, PharmD

Last reviewed on:

March 15, 2021


What is oxaprozin (Daypro)?

How oxaprozin (Daypro) works

Oxaprozin (Daypro) is a nonsteroidal anti-inflammatory drug (NSAID). It blocks the inflammatory process in your body, which relieves pain and swelling.

What is oxaprozin (Daypro) used for?

  • Juvenile rheumatoid arthritis
  • Osteoarthritis
  • Rheumatoid arthritis

Oxaprozin (Daypro) dosage forms

tablet icon

Typical dosing for oxaprozin (Daypro)

  • Osteoarthritis and rheumatoid arthritis: The typical dose is 1.2 grams (two 600 mg tablets) by mouth once a day. The maximum daily dose is 1.8 grams or 26 mg per kilogram bodyweight, whichever is lower, in divided doses.
  • Juvenile rheumatoid arthritis (children ages 6 to 16): Dose is based on body weight. The typical dose is 600 mg to 1.2 grams by mouth once a day.

Frequently asked questions about oxaprozin (Daypro)

Pros and cons of oxaprozin (Daypro)


Thumbs UpOxaprozin (Daypro) causes fewer gastrointestinal side effects than aspirin when used to treat rheumatoid arthritis.

Thumbs UpTypically taken once a day

Thumbs UpCan be used in both adults and children as young as 6 years old

Thumbs UpCan be taken at the same time as antacids, which may be helpful if you have stomach upset


Thumbs DownTakes several days for oxaprozin (Daypro) to reach its full effects

Thumbs DownNot recommended to use during pregnancy, especially during the third trimester

Thumbs DownMust avoid alcohol while on oxaprozin (Daypro) since it can raise your chance of stomach bleeding or ulcers

Thumbs DownIf you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.

Pharmacist tips for oxaprozin (Daypro)

Capsule IconFood can affect how fast oxaprozin (Daypro) is absorbed by the body, but won't affect how much is absorbed overall. If you notice an upset stomach or nausea after taking this medication, you can take it with food, but just be aware that it may take a little bit longer for the medication to kick in. You can also take an antacid, like Tums, for stomach-related side effects. Antacids don't have any effects on how oxaprozin (Daypro) is absorbed by your body.

Capsule IconIf you are allergic to aspirin, there is a chance you may be allergic to oxaprozin (Daypro) as well. Tell your provider about all your allergies.

Capsule IconThere are several over-the-counter (OTC) pain medications that can interact with oxaprozin (Daypro). Naproxen (Aleve) and ibuprofen (Advil) are in the same drug class as oxaprozin (Daypro), so be very careful not to combine these medications, because it can raise your risk for bleeding. Always ask your pharmacist or provider if a new medication is safe to take along with oxaprozin (Daypro).

Capsule IconIf you're age 65 or older, you're at a greater risk for stomach-related problems and kidney problems while taking this medication. You should take the lowest dose of oxaprozin (Daypro) for the shortest amount of time that's necessary to treat your pain.

Capsule IconOxaprozin (Daypro) can cause you to develop a mild skin reaction or rash when exposed to sunlight. Use sunscreen and wear protective clothing when you're outside to protect you from the sun.

Capsule IconAlthough you may notice some improvement in pain within the first few doses of oxaprozin (Daypro), it can take several days for you to see its full effects. Don't get discouraged if you don't see immediate or dramatic pain relief when you first start taking this medication.

Prices for oxaprozin (Daypro) start at just $37.76 with a GoodRx coupon. They’re fast, easy-to-use and free!

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What are the side effects of oxaprozin (Daypro)?

With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.

Warning Small Contact your doctor immediately if you experience any of the following:

  • Liver problems: nausea, fatigue, diarrhea, yellowing of skin or whites of the eyes
  • Kidney problems: irregular heartbeat, shortness of breath, poor urine output, confusion, weakness
  • Heart attack: chest pain, sweating, shortness of breath, pain or discomfort in jaw, neck, or shoulders
  • Gastrointestinal (GI) bleeding: black or tarry stool, dizziness, stomach pain or discomfort
  • Serious allergic reactions: hives, swelling of face, tongue, or throat, difficulty breathing
  • Serious skin reactions: flu-like symptoms, painful rash or blisters all over body, peeling of skin
  • Stroke: weakness on one side of the body, slurred speech, loss of balance, confusion
  • Heart failure: shortness of breath, swelling or fluid buildup in ankles, feet, or legs, cough

Caution Small The following side effects may get better over time as your body gets used to the medication. Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time.

Common side effects

  • Constipation
  • Diarrhea
  • Upset stomach or indigestion
  • Nausea
  • Rash

Other side effects

  • Stomach pain or discomfort
  • Loss of appetite
  • Vomiting
  • Gas
  • Dizziness
  • Headache
  • Ringing in ears
  • Low red blood cells

Source: DailyMed

The following side effects have also been reported:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Skin rash

Less common


bloody or black, tarry stools

burning upper abdominal or stomach pain

burning while urinating

cloudy urine


decrease in urine output or decrease in urine-concentrating ability


difficult or painful urination

frequent urination




itching skin

loss of appetite

nausea or vomiting

pale skin

severe abdominal or stomach pain, cramping, or burning

severe and continuing nausea


troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

vomiting of blood or material that looks like coffee grounds

weight loss



bleeding gums

blistering, peeling, or loosening of the skin

blurred vision

body aches or pain

burning feeling in chest or stomach

changes in blood pressure

chest pain

clay-colored stools



cough or hoarseness

cracks in the skin

dark urine


difficult or labored breathing

difficulty swallowing

dilated neck veins


ear congestion

extreme fatigue


feeling of discomfort

fever or chills

fluid-filled skin blisters

high fever

hives or welts


increased sensitivity of the skin to sunlight

increased thirst

increased volume of pale, dilute urine

inflammation of the joints

irregular, fast or slow, or shallow breathing

joint or muscle pain

large, flat, blue or purplish patches in the skin

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


light-colored stools


loss of heat from the body

loss of voice

lower back or side pain

muscle aches

muscle twitching

noisy breathing

pain or burning in the throat

pain or tenderness around the eyes and cheekbones

pale or blue lips, fingernails, or skin

pinpoint red or purple spots on the skin

pounding in the ears

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid weight gain

red skin lesions, often with a purple center

red, irritated eyes

redness or other discoloration of the skin

redness, swelling, or soreness of tongue

scaly skin


severe sunburn

skin thinness

slow, fast, irregular, pounding, or racing heartbeat or pulse


sore throat

sores, ulcers, or white spots on the lips or tongue or inside the mouth

stuffy or runny nose


swelling of the face, fingers, feet, or lower legs

swelling or inflammation of the mouth

swollen lymph glands

tenderness in the stomach area

tightness in the chest

unpleasant breath odor

upper right abdominal or stomach pain

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach


stomach discomfort

Less common

Continuing ringing or buzzing or other unexplained noise in the ears

excess air or gas in the stomach or intestines

hearing loss

passing gas

relaxed and calm

sleepiness or unusual drowsiness

trouble sleeping


Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

burning, dry, or itching eyes

change in taste

decreased hearing

discharge, excessive tearing

dry mouth

feeling of constant movement of self or surroundings

general feeling of discomfort or illness

lack or loss of strength

redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid

sensation of spinning

shakiness in the legs, arms, hands, feet

trembling or shaking of the hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

What are the risks and warnings for oxaprozin (Daypro)?

Oxaprozin (Daypro) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options

Heart attack and stroke

  • Risk factors: Long-term use | History of heart disease | History of heart bypass surgery (coronary artery bypass graft/CABG)

Black Box WarningTaking oxaprozin (Daypro) for long periods of time can raise your risk of heart attack or stroke, especially if you've had a history of heart disease or are planning a heart bypass surgery. Take oxaprozin (Daypro) for the shortest amount of time possible needed to control your symptoms in order to lower this risk. Talk to your provider about alternatives to oxaprozin (Daypro) if you're going to have heart bypass surgery.

Stomach bleeding

  • Risk factors: Age 65 or older | History of GI bleed or peptic ulcer disease | Longer duration of treatment | Use of oral corticosteroids, aspirin, anticoagulants, selective serotonin reuptake inhibitors (SSRIs) | Smoking | Alcohol use

Black Box WarningTaking oxaprozin (Daypro) can raise your risk of ulcers and bleeding in the stomach and intestines. Talk to your provider if you suddenly get sharp pains in your stomach or you notice bright, red blood in your vomit or dark, tarry stool.

Higher blood pressure

  • Risk factors: History of high blood pressure

Oxaprozin (Daypro) can raise your blood pressure, especially if you have a history of high blood pressure. Check your blood pressure regularly as instructed by your provider.

Worsening heart failure

  • Risk factors: Heart failure

Oxaprozin (Daypro) can worsen your symptoms of heart failure, including fluid buildup, which can lead to heart attacks and hospitalizations. Therefore, if you have heart failure, the risks and benefits of using oxaprozin (Daypro) should be discussed with your provider before starting this medication. If you have heart failure and are taking oxaprozin (Daypro), your provider will likely monitor you for signs of worsening heart failure.

Kidney problems

  • Risk factors: History of kidney problems | Dehydration | Heart failure | Liver problems | Taking diuretics (water pills) and ACE inhibitors or angiotensin receptor blockers (ARBs) | Age 65 or older

Oxaprozin (Daypro) and similar medications in the NSAID family can cause decreased kidney function or permanent kidney damage. In some cases, problems with your kidneys may raise the potassium levels in your blood. If you experience irregular heartbeat, shortness of breath, poor urine output, confusion, or weakness while taking this medication, let your provider know.

Liver problems

Oxaprozin (Daypro) and similar medications in the NSAID family can cause liver problems. Your provider might order blood tests to make sure that your liver is healthy. Let your provider know if you experience nausea, fatigue, diarrhea, yellowing of skin or whites of your eyes while taking this medication.

Serious allergic reactions

  • Risk factors: History of allergic reaction to aspirin or NSAIDs | Aspirin-sensitive asthma

If you've experienced a serious allergic reaction to aspirin or other NSAIDs in the past, then there's a chance that you may develop an allergic reaction to oxaprozin (Daypro) as well. Let your provider know about all of your allergies before starting this medication. If you experience hives, difficulty breathing, or swelling of the face, tongue, or throat after taking oxaprozin (Daypro), get medical help right away.

Life-threatening skin reactions

  • Risk factors: History of serious skin reactions to NSAIDs

Oxaprozin (Daypro) can cause life-threatening skin reactions such as painful rash or blisters all over the body and peeling of the skin. You may also experience flu-like symptoms. If this happens, you will need to stop taking this medication and switch to a different one.

Harm to your unborn baby

Oxaprozin (Daypro) is not recommended for use during pregnancy, especially during the third trimester, because it can cause serious harm to your unborn baby. If you're pregnant or think you may be pregnant, discuss with your provider about other safer medications.

Anemia (low red blood cell count)

  • Risk factors: Taking with other blood thinners (e.g. aspirin, warfarin) | Taking with selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs)

Oxaprozin (Daypro) can raise your risk of bleeding which can lead to anemia (low red blood cells). If you experience fatigue, weakness, pale skin, shortness of breath, or dizziness after taking this medication, let your provider know. Regular blood tests may need to be done to make sure that your red blood cells are within normal levels.

Sensitivity to sunlight

Oxaprozin (Daypro) can make your skin more sensitive to sunlight and cause you to develop a mild skin reaction or rash when exposed to the sun. Make sure to apply sunscreen and wear protective clothing when you're outside to protect your skin from the sun.

Interactions between oxaprozin (Daypro) and other medications

Oxaprozin (Daypro) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with oxaprozin (Daypro). Please note that only the generic name of each medication is listed below.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

How much does oxaprozin (Daypro) cost?

Oxaprozin (Daypro) is available as a generic medication and may be significantly cheaper compared to the brand version. Unless there is a specific reason you need the brand, the generic medication will be a better value. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price.

Lowest GoodRx Price
Daypro (brand)


Lowest GoodRx Price
oxaprozin (generic)


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Pricing based on most commonly-filled versions: 60 tablets of oxaprozin 600mg

What are alternatives to oxaprozin (Daypro)?

There are a number of medications that your doctor can prescribe in place of oxaprozin (Daypro). Compare a few possible alternatives below.

Oxaprozin (Daypro)
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