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Mefenamic Acid

Mefenamic Acid Side Effects

Robert Chad Hakim, PharmD, BCCCPAllison Gourley, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Allison Gourley, PharmD
Last reviewed on March 19, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Stomach pain
  • Nausea
  • Upset stomach or indigestion
  • Gas
  • Diarrhea
  • Constipation
  • Heartburn
  • Vomiting
  • Dizziness
  • Headache
  • Rash

Less Common Side Effects

  • Dry mouth
  • Fast heart rate
  • Fever
  • Infection
  • High blood pressure
  • Anxiety
  • Shortness of breath
  • Blurred vision

Mefenamic Acid serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Stomach bleeding: feeling faint, vomiting blood, bloody or dark stools, severe stomach pain or discomfort
  • Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw
  • Stroke: chest pain, trouble breathing, weakness in one part of your body or face, slurred speech
  • Heart failure: difficulty breathing, swelling, fast heartbeat
  • Liver problems: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine
  • Kidney problems: tiredness, dry and itchy skin, low appetite, urinating less than usual, foamy or bloody urine, muscle cramps
  • Allergic reactions: hives, rash, blisters, swelling of the lips or tongue, difficulty breathing
  • Serious skin reactions: skin reddening, blisters, rash
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Source: DailyMed

The following Mefenamic Acid side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Bloody urine

bloody, black, or tarry stools

decreased frequency or amount of urine

heartburn

increased bleeding time

increased blood pressure

increased thirst

indigestion

itching skin

loss of appetite

lower back or side pain

nausea

pale skin

rashes

severe abdominal pain, cramping, or burning

stomach bloating

swelling of the face, fingers, feet, or lower legs

trouble breathing with or without exertion

unusual bleeding or bruising

unusual tiredness or weakness

vomiting

vomiting of material that looks like coffee grounds, severe and continuing

weight gain

weight loss

Less common

Bleeding gums

blood in vomit

blurred vision

burning feeling in the chest or stomach

chest pain

clay-colored stools

cloudy urine

confusion

constipation

cough or hoarseness

dark urine

difficult or labored breathing

difficult, burning, or painful urination

difficulty in swallowing

dilated neck veins

dizziness

extreme fatigue

fainting

fast, pounding, or irregular heartbeat or pulse

fever or chills

frequent urge to urinate

headache

increased volume of pale, dilute urine

irregular breathing

irregular heartbeat

large, flat, blue, or purplish patches in the skin

light-colored stools

lightheadedness

nervousness

noisy breathing

pain or burning feeling in the throat

pinpoint red or purple spots on the skin

pounding in the ears

rapid, slow breathing

redness, swelling, or soreness of the tongue

severe or continuing stomach pain

slow heartbeat

sore throat

sores, ulcers, or white spots on the lips or tongue or inside the mouth

stomach upset

swelling or inflammation of the mouth

swollen glands

tenderness in the stomach area

tightness in the chest

tremors

unpleasant breath odor

upper right stomach pain

yellow eyes and skin

Rare

Blistering, peeling, or loosening of the skin

change in consciousness

chest discomfort

continuing vomiting

cracks in the skin

diarrhea

dizziness, faintness, or lightheadedness when suddenly getting up from a lying or sitting position

drowsiness

fever with or without chills

flushed, dry skin

fruit-like breath odor

general body swelling

general feeling of illness

high fever

hives

increased hunger

irregular, fast or slow, or shallow breathing

joint or muscle pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

leg pain

loss of consciousness

loss of heat from the body

no blood pressure

no breathing

no pulse

nosebleeds

painful glands

pain or discomfort in the arms, jaw, back, or neck

pains in the stomach, side, or abdomen, possibly radiating to the back

pale or blue lips, fingernails, or skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

racing heartbeat or pulse

red skin lesions, often with a purple center

red, irritated eyes

red, swollen skin

redness or soreness of the skin

scaly skin

seeing, hearing, or feeling things that are not there

seizures

severe headache

sneezing

sores, welting, or blisters

stiff neck or back

sweating

swollen, painful, or tender lymph glands in the neck, armpit, or groin

unexplained weight loss

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Continuing ringing or buzzing or other unexplained noise in the ears

excess air or gas in the stomach or intestines

feeling of fullness

hearing loss

passing gas

stomach discomfort

Less common

Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

discouragement

dry mouth

fear

feeling of constant movement of self or surroundings

feeling sad or empty

hair loss, thinning of the hair

increased sensitivity of the skin to sunlight

irritability

lack of appetite

lack of interest or pleasure

lack or loss of strength

redness or other discoloration of the skin

sensation of spinning

severe sunburn

sleepiness

trouble concentrating

trouble sleeping

Rare

Appetite changes

burning, dry, or itching eyes

change in hearing

discharge, excessive tearing

redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

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