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Nabumetone

Nabumetone Side Effects

Robert Chad Hakim, PharmD, BCCCPCydnee Ng, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Cydnee Ng, PharmD
Last reviewed on November 7, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (14%)
  • Indigestion (13%)
  • Stomach pain (12%)
  • Constipation (up to 9%)
  • Gas (up to 9%)
  • Nausea (up to 9%)
  • Dizziness (up to 9%)
  • Headache (up to 9%)
  • Itching (up to 9%)
  • Rash (up to 9%)
  • Ringing in the ears (up to 9%)
  • Swelling (up to 9%)

Less Common Side Effects

  • Vomiting
  • Fatigue
  • Sleepiness
  • Trouble sleeping
  • Nervousness

Nabumetone serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Stomach ulcer: gnawing pain in the stomach, acid reflux, feel full quickly
  • Stomach bleeding: feeling faint, vomiting blood, bloody or dark stools, severe stomach pain or discomfort
  • Heart attack: chest pain or tightness; pain that spreads to your shoulder, arm, neck, or jaw; sweating
  • Stroke: chest pain, trouble breathing, weakness in one part of your body or face, blurred vision, slurred speech, severe headache
  • Heart failure: trouble breathing, swelling, sudden weight gain, tiredness, dizziness
  • Kidney problems: urinating less than usual, foamy or bloody urine, muscle cramps, low appetite, tiredness, dry and itchy skin
  • Liver problems: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine
  • Serious allergic reaction: hives, rash, swelling of the face, swelling of the lips or tongue, trouble breathing, fever, swollen lymph nodes
  • Serious skin reactions: rash, skin reddening, blisters, peeling skin

Source: DailyMed

The following Nabumetone side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Headache

itching skin

nausea

rash

stomach pain

swelling

Less common

Burning feeling in chest or stomach

indigestion

stomach upset

swelling or inflammation of the mouth

tenderness in stomach area

vomiting

Rare

Bleeding gums

blistering, peeling, loosening of skin

bloody or black, tarry stools

bloody or cloudy urine

burning upper abdominal pain

changes in vision

chest pain

chills

clay-colored stools

constipation

cough

dark-colored urine

diarrhea

difficult or labored breathing

difficulty swallowing

dizziness

dry cough

dry mouth

fast heartbeat

fever

fluid-filled skin blisters

general feeling of tiredness or weakness

greatly decreased frequency of urination or amount of urine

high blood pressure

hives or welts

increased sensitivity of skin to sunlight

increased thirst

joint pain, stiffness, or swelling

large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs

light-colored stools

loss of appetite

muscle pain

pain in lower back or side

pinpoint red spots on skin

puffiness or swelling of the eyelids or around the eyes, face, lips or tongue

rapid breathing

red irritated eyes

red skin lesions, often with a purple center

redness or other discoloration of skin

severe or continuing stomach pain

severe sunburn

shortness of breath

skin thinness

sore throat

sores, ulcers, or white spots in mouth or on lips

stomach bloating, burning, or cramping

swelling of face, fingers, feet or lower legs

tightness in chest

unpleasant breath odor

unusual bleeding or bruising

unusual tiredness or weakness

vaginal bleeding

vomiting of blood or material that looks like coffee grounds

weight gain or loss

wheezing

yellow eyes or skin

Symptoms of overdose

Agitation

blurred vision

coma

confusion

depression

hostility

irregular, fast or slow, or shallow breathing

irritability

muscle twitching

nervousness

pain or discomfort in chest, upper stomach, or throat

pale or blue lips, fingernails, or skin

pounding in the ears

seizures

severe stomach pain

slow heartbeat

stupor

unusual drowsiness, dullness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

belching

bloated full feeling

continuing ringing or buzzing or other unexplained noise in ears

excess air or gas in stomach or intestines

hearing loss

indigestion

mild diarrhea

passing gas

Less common

Increased sweating

sleepiness or unusual drowsiness

sleeplessness

trouble sleeping

unable to sleep

Rare

Anxiety

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

feeling of constant movement of self or surroundings

general feeling of discomfort or illness

increased appetite

lack or loss of strength

lightheadedness

sensation of spinning

shakiness in legs, arms, hands, feet

trembling or shaking of hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.

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