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Sulindac

Sulindac Side Effects

Connie Zheng, PharmDDaisy Chau, PharmD
Reviewed by Connie Zheng, PharmD, Daisy Chau, PharmD
Last reviewed on November 15, 2021

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Stomach pains (10%)
  • Heartburn (3-9%)
  • Nausea (3-9%)
  • Diarrhea (3-9%)
  • Constipation (3-9%)
  • Rash (3-9%)
  • Dizziness (3-9%)
  • Headache (3-9%)

Less Common Side Effects

  • Passing gas
  • Stomach cramps
  • Itchy and dry skin
  • Nervousness
  • Ringing in the ear
  • Swelling of the arms and legs

Sulindac serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Heart attack: dizziness, tiredness, cold sweat, trouble breathing, chest pain or tightness, anxiety
  • Stroke: tiredness, lightheadedness, blurred vision, difficulty speaking, difficulty walking, weakness on one side of the body
  • Stomach bleeds: blood in your vomit, stool that looks like black coffee grounds, pain in your stomach that doesn't go away
  • Heart failure: trouble breathing, tiredness, swelling in your body, sudden weight gain
  • Kidney damage: nausea, vomiting, tiredness, loss of appetite, changes in how much you urinate
  • Liver damage: fever, chills, fatigue, nausea, vomiting, yellowing of the skin or whites of the eyes, clay-colored stool, and dark urine
  • Severe asthma attack: chest pain, cough, difficulty breathing, wheezing
  • Serious allergic and skin reaction: fever, rash, body aches, cough, swelling of the face, peeling skin, painful blisters all over your body

Source: DailyMed

The following Sulindac side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Acid or sour stomach

belching

constipation

headache

heartburn

nausea or vomiting

skin rash

stomach pain

Less common

Excess air or gas in the stomach or intestines

itching skin

passing gas

stomach cramps

swelling

weight loss

Rare

Back or leg pains

bleeding gums

blistering, peeling, or loosening of the skin

bloating

bloody or black, tarry stools

bloody or cloudy urine

blurred or loss of vision

burning feeling in the chest or stomach

burning while urinating

chest pain

chills

clay-colored stools

confusion

cough or hoarseness

cracks in the skin

dark urine

decreased urine output

diarrhea

difficult or labored breathing

difficult or painful urination

difficulty with swallowing

dilated neck veins

discoloration of urine

disturbed color perception

dizziness

double vision

extreme fatigue

eye pain

fainting

feeling of warmth

fever

flu-like symptoms

general body swelling

general feeling of discomfort or illness

groin pain

halos around lights

hives

increased sensitivity of the skin to sunlight

increased sweating

increased thirst

indigestion

irregular breathing

joint or muscle pain

large, flat, blue, or purplish patches in the skin

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

light-colored stools

loss of appetite

loss of heat from the body

lower back or side pain

muscle aches, pains, or weakness

nervousness

night blindness

noisy breathing

nosebleeds

numbness or tingling in the hands, feet, or lips

overbright appearance of lights

painful or difficult urination

pains in the stomach, side, or abdomen, possibly radiating to the back

pale skin

persistent bleeding or oozing from puncture sites, mouth, or nose

pinpoint red or purple spots on the skin

pounding in the ears

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red skin lesions, often with a purple center

red, irritated eyes

redness of the face, neck, arms and occasionally, upper chest

redness or other discoloration of the skin

redness, swelling, or soreness of the tongue

scaly skin

seizures

severe or continuing stomach pain

severe sunburn

shortness of breath

slow or fast, irregular, pounding, or racing heartbeat or pulse

sore throat

sores, ulcers, or white spots in the mouth or on the lips

stiff neck or back

stomach upset

swelling of the face, fingers, feet, or lower legs

swelling or inflammation of the mouth

swollen or painful glands

tenderness in the stomach area

tightness in the chest

troubled breathing

tunnel vision

unpleasant breath odor

unusual bleeding or bruising

unusual tiredness or weakness

upper right abdominal pain

vomiting of blood or material that looks like coffee grounds

watery or bloody diarrhea

weakness or heaviness of the legs

weight gain

wheezing

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Change in consciousness

decreased awareness or responsiveness

loss of consciousness

severe sleepiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Continuing ringing or buzzing or other unexplained noise in the ears

hearing loss

Rare

Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

burning, dry, or itching eyes

decreased hearing

difficulty with moving

discharge, excessive tearing

discouragement

false sense of well-being

feeling of constant movement of self or surroundings

feeling sad or empty

hair loss or thinning of the hair

hallucinations

irritability

loss of interest or pleasure

metallic or bitter taste

mood swings

muscle cramping or stiffness

personality changes

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

restlessness

sensation of spinning

sleepiness or unusual drowsiness

sleeplessness

sore or dry mucous membranes

swelling or redness in the joints

trouble with concentrating

trouble with sleeping

unable to sleep

vaginal bleeding

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Connie Zheng, PharmD, is a drug information pharmacist at GoodRx and a licensed pharmacist in California. She has over 6 years of experience working in independent pharmacies.
Daisy Chau, PharmD
Reviewed by:
Daisy Chau, PharmD
Daisy Chau, PharmD, is the drug information pharmacist manager at GoodRx. She is licensed in California and has more than 6 years of experience working as a pharmacist in drug information.

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