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Ketoprofen

Ketoprofen Side Effects

Robert Chad Hakim, PharmD, BCCCPCydnee Ng, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Cydnee Ng, PharmD
Last reviewed on February 21, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Indigestion (11%)
  • Nausea (up to 9%)
  • Stomach pain (up to 9%)
  • Diarrhea (up to 9%)
  • Constipation (up to 9%)
  • Passing gas (up to 9%)
  • Headache (up to 9%)

Less Common Side Effects

Ketoprofen serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Stomach bleeding: feeling faint, vomiting blood, bloody or dark stools, severe stomach pain or discomfort
  • Heart attack: chest pain or tightness; pain that spreads to your shoulder, arm, neck, or jaw; sweating
  • Stroke: difficulty breathing, weakness on one side of your body or face, blurred vision, slurred speech, severe headache
  • Heart failure: difficulty breathing, swelling, sudden weight gain, tiredness, dizziness
  • Kidney problems: urinating less than usual, foamy or bloody urine, muscle cramps, low appetite, tiredness, dry and itchy skin
  • Serious allergic reaction or serious skin reaction: hives, rash, blisters, skin reddening, peeling skin, swelling of the face, swelling of the lips or tongue, difficulty breathing

Source: DailyMed

The following Ketoprofen side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Abdominal pain

bloody urine

decreased frequency or amount of urine

headache

increased blood pressure

increased thirst

loss of appetite

lower back or side pain

nausea

swelling of face, fingers, feet, or lower legs

troubled breathing

unusual tiredness or weakness

vomiting

weight gain

Less common

Bladder pain

cloudy urine

difficult, burning, or painful urination

frequent urge to urinate

rash

swelling or inflammation of the mouth

Rare

Back pain

bleeding from rectum

bleeding gums

blistering, peeling, loosening of skin

blood in vomit

bloody nose

bloody, black, or tarry stools

blurred vision

body aches or pain

burning feeling in chest or stomach

burning, dry or itching eyes

change in color of eye

chest pain

chills

clay-colored stools

cold hands and feet

coma

confusion

congestion

constipation

convulsions

cough or hoarseness

coughing or spitting up blood

cracks in the skin

dark urine

decreased urination

decreased vision or other changes in vision

diarrhea

difficult or labored breathing

difficulty swallowing

dilated neck veins

discharge, excessive tearing

dryness or soreness of throat

extreme fatigue

fast, irregular, pounding, or racing heartbeat or pulse

feeling faint, dizzy, or lightheadedness

feeling of warmth or heat

fever with or without chills

flushing or redness of skin, especially on face and neck

general tiredness and weakness

heartburn

hives or welts

increased sensitivity of skin to sunlight

indigestion

itching

joint or muscle pain

light-colored stools

loss of heat from the body

muscle pain or cramps

nervousness

noisy breathing

pale or blue lips, fingernails, or skin

pale skin

pinpoint red or purple spots on skin

pounding in the ears

problems with bleeding or clotting

puffiness or swelling of the eyelids or around the eyes, face, lips or tongue

red skin lesions, often with a purple center

red, irritated eyes

red, swollen skin

redness or other discoloration of skin

redness or soreness around fingernails or loosening of the fingernails

redness, pain, swelling of eye, eyelid, or inner lining of eyelid

runny nose

scaly skin

severe abdominal cramping

severe or continuing stomach pain

severe sunburn

shortness of breath

skin rash, encrusted, scaly and oozing

slow heartbeat

slow or irregular breathing

sores, ulcers, or white spots on lips or in mouth

stomach pain or upset

sweating

swelling of face, ankles, or hands

tender, swollen glands in neck

tenderness in stomach area

tightness in chest

trouble in swallowing

troubled breathing with exertion

unpleasant breath odor

unusual bleeding or bruising

upper right abdominal pain

voice changes

vomiting of blood

vomiting of material that looks like coffee grounds, severe and continuing

wheezing

yellow eyes or skin

Symptoms of overdose

Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

fast or shallow breathing

pain or discomfort in chest, upper stomach, or throat

unusual drowsiness, dullness, tiredness, weakness or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

belching

bloated

discouragement

dreams

excess air or gas in stomach or intestines

excitation

feeling sad or empty

full feeling

general feeling of discomfort or illness

irritability

lack of appetite

loss of interest or pleasure

passing gas

sleepiness

sleeplessness

trouble concentrating

trouble sleeping

unable to sleep

Less common

Continuing ringing or buzzing or other unexplained noise in ears

disturbed color perception

double vision

halos around lights

hearing loss

loss of vision

night blindness

overbright appearance of lights

tunnel vision

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.

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