Compare Zoladex vs. Lupron

Zoladex (goserelin) and leuprolide (Lupron) are both GnRH agonists used to treat advanced prostate cancer, but they have some differences. Zoladex is available as an implant that is injected under the skin of your stomach every 4 weeks or every 3 months, while leuprolide is given as a daily injection under the skin. Zoladex is also used to treat breast cancer and endometriosis in women and leuprolide is often used off-label for fertility treatments. Zoladex can cause weaker bones, requiring calcium and vitamin D supplements, while leuprolide can lead to injection site reactions and a temporary worsening of prostate cancer symptoms. Additionally, both medications are only available as a brand-name medications, can cause hot flashes, and increase risks related to heart problems and high blood sugar levels.