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Xalatan vs. Combigan

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Latanoprost (Xalatan) and Combigan (brimonidine/timolol) are both used to lower eye pressure in conditions like glaucoma and ocular hypertension, but they work differently and have distinct characteristics. Latanoprost is a prostaglandin that helps fluid drain from the eye, and it's typically used once daily in the evening. Combigan, on the other hand, is a combination of an alpha agonist (brimonidine) and a beta blocker (timolol), which both reduce fluid production and help fluid flow out of the eye, and it is used twice a day. Latanoprost can cause changes in eye color and eyelash growth, while Combigan can affect your blood pressure and is not suitable for people with certain heart or lung conditions. Latanoprost is available in a generic form, making it more affordable, whereas Combigan is only available as a brand medication, which can be more expensive. Both medications require careful handling to avoid contamination and should not be used with contact lenses in place.

Latanoprost

(Xalatan)

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Combigan

(brimonidine / timolol)

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Summary for Xalatan

Prescription only

Latanoprost (Xalatan) is an eye drop medication. It's used in adults to treat conditions related to high pressure in the eye, such as glaucoma. It works as a prostaglandin to help with high eye pressure. The typical dosage is 1 drop in the affected eye(s) once each night. Side effects include feeling like there's something in the eye, burning, and stinging. Unopened bottles need to be refrigerated. But once opened, you keep the medication at room temperature. Latanoprost (Xalatan) is available as a brand-name and generic medication.

Indications for Xalatan

Pros and Cons for Xalatan

Pros

Cons

  • Can permanently change the color of your eye
  • Need to take out any soft contact lenses before using

Common Side Effects for Xalatan

  • Feeling like there's something inside the eye (13%)
  • Stinging (9%)
  • Eye redness (8%)
  • Blurry vision (8%)
  • Itchy eye (8%)
  • Burning (7%)
  • Changes in eye color (7%)

Warnings for Xalatan

  • Darker eyes or eyelids
  • Eyelash changes
  • Eye inflammation
  • Swelling of the retina (macular edema)
  • Caution use in people with a history of a herpes eye infection
  • Risk of bacterial eye infection when using contaminated medication
  • Don't use while wearing soft contact lenses

Summary for Combigan

Prescription only

Combigan is a combination eye drop containing brimonidine (an alpha agonist) and timolol (a beta blocker). It's used to lower high pressure inside the eye in adults with conditions like glaucoma or ocular hypertension. Typically, you apply one drop to the affected eye(s) twice daily, about 12 hours apart. Common side effects include eye redness, itching, or dryness. Combigan (brimonidine / timolol) is available as both a brand-name and generic medication.

Indications for Combigan

Treatment of high pressure in the eye in people ages 2 years and older with:

Pros and Cons for Combigan

Pros

  • Convenient to have a single eye drop that combines two different medications
  • Can be stored at room temperature
  • Possible option for children older than 2 years old

Cons

  • Used twice a day
  • Can cause tiredness or drowsiness in some people
  • Not for people with asthma, severe chronic obstructive pulmonary disease (COPD), or certain heart-related problems

Common Side Effects for Combigan

Reported in up to 15% of people in clinical studies:

  • Eye redness
  • Eye itching
  • Eye burning or stinging

Warnings for Combigan

  • Only use in the eye
  • Allergic reaction of the eye
  • Interaction with inhaled beta agonists for asthma or COPD
  • Worsening heart problems
  • Worsening of other medical conditions
  • Masked symptoms of low blood sugar in people with diabetes
  • Masked symptoms of high thyroid hormone levels (hyperthyroidism)

Prices with our coupons for Xalatan vs. Combigan

Price Card Drug Icon
Latanoprost1 eye dropper / 2.5ml of 0.005%
$13.85$18.87
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Price Card Drug Icon
Brimonidine/Timolol1 eye dropper / 5ml of 0.2%/0.5%
$29.64$242.60
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