Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Travoprost (Travatan Z) and Combigan (brimonidine/timolol) are both used to lower eye pressure in conditions like glaucoma and high eye pressure, but they work differently. Travoprost is a prostaglandin eye drop that helps fluid drain from the eye, and you only need to apply it once a day at night. In contrast, Combigan combines an alpha agonist (brimonidine) and a beta blocker (timolol) to reduce fluid production and improve fluid flow, requiring application twice a day. Travoprost can cause eye redness and potentially permanent changes in eye color, whereas Combigan can cause low blood pressure and is not recommended if you have asthma, COPD, or heart issues. Both medications require you to remove contact lenses before use and wait 15 minutes before reinserting them. Additionally, travoprost and Combigan are both available as a lower-cost generics.
Travoprost (Travatan Z)
Combigan (brimonidine / timolol)
Travoprost (Travatan Z)
Combigan (brimonidine / timolol)
Summary of Travatan Z vs. Combigan
Summary for Prostaglandin
Prescription only
Travoprost (Travatan Z) is a prescription prostaglandin eye drop that helps lower pressure in the eye. It's a first-choice medication for treating glaucoma in people over the age of 16. Typically, you apply travoprost (Travatan Z) once a day at night. This medication can cause eye redness and changes to eye color as side effects. It's available as a brand name and generic medication.
Summary for Alpha agonist / Beta blocker
Prescription only
Combigan is a combination eye drop containing brimonidine (an alpha agonist) and timolol (a beta blocker). It's used to lower high pressure inside the eye in adults with conditions like glaucoma or ocular hypertension. Typically, you apply one drop to the affected eye(s) twice daily, about 12 hours apart. Common side effects include eye redness, itching, or dryness. Combigan (brimonidine / timolol) is available as both a brand-name and generic medication.