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Zioptan vs. Combigan

Zioptan (tafluprost) is an eye drop medication used to treat high pressure in the eye, such as glaucoma. It works as a prostaglandin to help relieve pressure in the eye. Zioptan (tafluprost) is for adults and is used once each night. Side effects include feeling like there's something in the eye, burning, and stinging. Zioptan (tafluprost) is available as a brand-name and now also a generic medication.

• High pressure in the eye in people with open-angle glaucoma or ocular hypertension

• Eye redness (up to 20%)
• Eye stinging or irritation (7%)
• Headache (6%)
• Itchy eye (5%)

• Darker eyes or eyelids
• Eyelash changes
• Eye inflammation
• Swelling of the retina (macular edema)

Combigan is a combination eye drop containing brimonidine (an alpha agonist) and timolol (a beta blocker). It's used to lower high pressure inside the eye in adults with conditions like glaucoma or ocular hypertension. Typically, you apply one drop to the affected eye(s) twice daily, about 12 hours apart. Common side effects include eye redness, itching, or dryness. Combigan (brimonidine / timolol) is available as both a brand-name and generic medication.

Treatment of high pressure in the eye in people ages 2 years and older with:

• Ocular hypertension
• Open-angle glaucoma

Reported in up to 15% of people in clinical studies:

• Eye redness
• Eye itching
• Eye burning or stinging

• Only use in the eye
• Allergic reaction of the eye
• Interaction with inhaled beta agonists for asthma or COPD
• Worsening heart problems
• Worsening of other medical conditions
• Masked symptoms of low blood sugar in people with diabetes
• Masked symptoms of high thyroid hormone levels (hyperthyroidism)