Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Dorzolamide (Trusopt) and brinzolamide (Azopt) are both carbonic anhydrase inhibitors used to treat high eye pressure in people with ocular hypertension or open-angle glaucoma. They are similar in that they both lower eye pressure by reducing the amount of fluid in the eye. However, there are several differences between the two medications. Dorzolamide is available only as a generic, while brinzolamide is available as both a brand (Azopt) and a generic, though brinzolamide tends to be more expensive. Both medications are applied as eye drops three times a day and can cause burning or stinging in the eye and a unusual taste. Both medications are not suitable for people with sulfa allergies, as they can cause allergic reactions. Additionally, brinzolamide is not recommended for people with severe kidney disease, while dorzolamide does not have this specific warning. Both medications can be used with other eye drops, but you should wait a few minutes between applying different medications.
Dorzolamide
Brinzolamide (Azopt)
Dorzolamide
Brinzolamide (Azopt)
Summary of Trusopt vs. Azopt
Summary for Carbonic anhydrase inhibitor
Prescription only
Dorzolamide is an eye drop medication used to treat high pressure in the eye in people with glaucoma or ocular hypertension. The dosage is 1 drop applied directly into the affected eye(s) three times per day. It's available as a generic only as the brand-name medication Trusopt has been discontinued. Dorzolamide is a sulfa medication, so it might not be the best choice if you have a serious sulfa allergy. Side effects include burning or stinging in the eye and a bitter taste in the mouth.
Summary for Carbonic anhydrase inhibitor
Prescription only
Brinzolamide (Azopt) is an eye drop that helps lower pressure within the eye and treats glaucoma. It is now available as a generic medication, but it still tends to be more expensive than other alternatives.
Indications of Trusopt vs. Azopt
Indications for
Treatment of high pressure in the eye in people with: