Key takeaways
Wakix (pitolisant) and armodafinil (Nuvigil) are both used to treat excessive daytime sleepiness from narcolepsy, but they work in different ways and have different uses. Wakix is a histamine-3 (H3) receptor antagonist/inverse agonist that treats narcolepsy-related cataplexy and daytime sleepiness. Armodafinil, on the other hand, is used for narcolepsy, obstructive sleep apnea, and shift work disorder. Wakix is not a controlled substance, while armodafinil is a Schedule IV controlled substance, indicating a potential for abuse. Wakix is taken once daily in the morning, and its effects can take a couple of months to fully develop, whereas armodafinil also requires once-daily dosing but starts to work in about an hour. Both medications can interact with hormonal birth control, but Wakix is specifically noted for its potential to cause life-threatening heart rhythm changes, especially if you’re taking other medications that cause changes in heart rhythm. Additionally, armodafinil carries risks of serious allergic reactions and mental health issues, such as worsening depression or mania.
