Key takeaways
Latanoprostene bunod (Vyzulta) and latanoprost (Xalatan) are both prostaglandin medications used to lower eye pressure in conditions like open-angle glaucoma and ocular hypertension. They are similar in that they are both administered as eye drops once daily in the evening. However, latanoprostene bunod is unique because it releases nitric oxide in addition to latanoprost acid, which helps drain eye fluid through two pathways, potentially making it more effective at lowering eye pressure. Latanoprost is available as both a brand-name and generic medication, while latanoprostene bunod is only available as a brand-name medication. Common side effects of latanoprostene bunod include eye redness and pain, whereas latanoprost may cause a feeling of something in the eye, burning, and stinging. Both medications can cause changes in eye color and eyelash growth, and they contain the preservative benzalkonium chloride, which can affect soft contact lenses.
