Compare Rocklatan vs. Vyzulta
Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Rocklatan (netarsudil/latanoprost) and Vyzulta (latanoprostene bunod) are both eye drop medications used to lower high pressure in the eye, such as in glaucoma. Rocklatan is a combination of two medications: netarsudil, a ROCK inhibitor, and latanoprost, a prostaglandin. Vyzulta, on the other hand, contains latanoprostene bunod, which is another prostaglandin. Unlike other prostaglandins, Vyzulta is the only one that also releases nitric oxide along with latanoprost acid, working in two ways to help lower eye pressure. While both medications are used once daily in the evening, Rocklatan needs to be refrigerated initially but can be stored for up to 6 weeks after opening, whereas Vyzulta can be stored at room temperature for up to 8 weeks after opening. Rocklatan is currently only available as a brand-name product, with no generic version expected before 2034, while Vyzulta also does not have a generic form. Both medications can cause side effects like eye redness and pain, and they can also darken the color of your eyes, eyelashes, and eyelids. However, Rocklatan may cause additional side effects such as corneal deposits and a red spot in the eye.
- Rocklatan (netarsudil / latanoprost)Vyzulta (latanoprostene bunod)
- Rocklatan (netarsudil / latanoprost)Vyzulta (latanoprostene bunod)
Summary of Rocklatan vs. Vyzulta
Summary for ROCK inhibitor / ProstaglandinPrescription onlyRocklatan is a combination eye drop that contains two medications: netarsudil (a ROCK or rho-kinase inhibitor) and latanoprost (a prostaglandin). Rocklatan is approved for use in adults to treat conditions related to high pressure in the eye, including glaucoma. It's given as a drop into the affected eye(s) once daily in the evening. Rocklatan (netarsudil / latanoprost) should be refrigerated, but it can be stored at room temperature for up to 6 weeks after opening. Side effects include eye redness and eye pain. It's also possible for the medication to cause iris color changes.
Summary for ProstaglandinPrescription onlyLatanoprostene bunod ophthalmic solution, also known by its brand name Vyzulta, is the only prostaglandin that also releases nitric oxide along with latanoprost acid, working in two ways to help lower eye pressure. This eye drop medication is used to treat conditions related to high pressure in the eye, such as glaucoma. Vyzulta (latanoprostene bunod) is approved for people 17 years of age and older. It's given as a drop into the affected eye(s) once daily in the evening. Bottles should be refrigerated, but they can be stored at room temperature for up to 8 weeks after opening. Side effects include eye redness and eye pain.
Indications of Rocklatan vs. Vyzulta
Indications for•Lowering pressure in the eye in people with ocular hypertension (high pressure in the eye) or open-angle glaucomaIndications for•Lowering pressure in the eye in people with ocular hypertension (high pressure in the eye) or open-angle glaucomaPros and Cons of Rocklatan vs. Vyzulta
Pros and Const for ROCK inhibitor / ProstaglandinPros•Contains latanoprost as one of the active ingredients, which is a first-choice treatment option for glaucoma•Combines two medications into a single eye drop for convenience•Convenient once-a-day dosingCons•Can permanently darken the color of your eyes•No lower-cost generic available; brand-name medication onlyPros and Const for ProstaglandinPros•Once-a-day eye drop•Can use with other eye pressure-lowering medicationsCons•Can change the color of your eyes•No lower-cost generic available; brand-name medication only•Not recommended for children age 16 and younger because of possible permanent changes to eye color with long-term useCommon Side Effects of Rocklatan vs. Vyzulta
Common Side Effects for•Eye redness (59%)•Eye pain after placing the drop into the eye (20%)•Corneal deposits (15%)•Red spot in the eye (popped blood vessel in the eye; 11%)Common Side Effects for•Red eyes (6%)•Eye irritation (4%)•Eye pain (3%)•Eye pain after placing the drop into the eye (2%)Warnings of Rocklatan vs. Vyzulta
Common Side Effects for•Darker eyes, eyelashes, or eyelids•Eyelash changes•Eye inflammation•Swelling of the retina (macular edema)•Risk for bacterial or viral eye infection when using contaminated medication•Don't use while wearing soft contact lensesCommon Side Effects for•Darker eyes, eyelashes, or eyelids•Eyelash changes•Eye inflammation•Swelling of the retina (macular edema)•Risk for bacterial infection in the eye when using contaminated medication•Don't use while wearing soft contact lensesPrices with our coupons for Rocklatan vs. Vyzulta
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