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Compare Rocklatan vs. Vyzulta

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Rocklatan (netarsudil/latanoprost) and Vyzulta (latanoprostene bunod) are both eye drop medications used to lower high pressure in the eye, such as in glaucoma. Rocklatan is a combination of two medications: netarsudil, a ROCK inhibitor, and latanoprost, a prostaglandin. Vyzulta, on the other hand, contains only latanoprostene bunod, which is also a prostaglandin. While both medications are used once daily in the evening, Rocklatan needs to be refrigerated initially but can be stored for up to 6 weeks after opening, whereas Vyzulta can be stored at room temperature for up to 8 weeks after opening. Rocklatan is currently only available as a brand-name product, with no generic version expected before 2034, while Vyzulta also does not have a generic form. Both medications can cause side effects like eye redness and pain, and they can also darken the color of your eyes, eyelashes, and eyelids. However, Rocklatan may cause additional side effects such as corneal deposits and a red spot in the eye.

  • Rocklatan (netarsudil / latanoprost)
    Vyzulta (latanoprostene bunod)
  • Rocklatan (netarsudil / latanoprost)
    Vyzulta (latanoprostene bunod)

  • Summary of Rocklatan vs. Vyzulta

    Summary for ROCK inhibitor / Prostaglandin
    Prescription only

    Rocklatan is a combination eye drop that contains two medications: netarsudil (a ROCK or rho-kinase inhibitor) and latanoprost (a prostaglandin). Rocklatan is approved for use in adults to treat conditions related to high pressure in the eye, including glaucoma. It's given as a drop into the affected eye(s) once daily in the evening. Rocklatan (netarsudil / latanoprost) should be refrigerated, but it can be stored at room temperature for up to 6 weeks after opening. Side effects include eye redness and eye pain. It's also possible for the medication to cause iris color changes.

    Summary for Prostaglandin
    Prescription only

    Latanoprostene bunod ophthalmic solution, also known by its brand name Vyzulta, is a prostaglandin. This eye drop medication is used to treat conditions related to high pressure in the eye, such as glaucoma. Vyzulta (latanoprostene bunod) is approved for people 17 years of age and older. It's given as a drop into the affected eye(s) once daily in the evening. Vyzulta (latanoprostene bunod) bottles should be refrigerated, but they can be stored at room temperature for up to 8 weeks after opening. Side effects include eye redness and eye pain.

  • Indications of Rocklatan vs. Vyzulta

    Indications for
    •Lowering pressure in the eye in people with ocular hypertension (high pressure in the eye) or open-angle glaucoma
    Indications for
    •Lowering pressure in the eye in people with ocular hypertension (high pressure in the eye) or open-angle glaucoma

  • Pros and Cons of Rocklatan vs. Vyzulta

    Pros and Const for ROCK inhibitor / Prostaglandin
    Pros
    •Contains latanoprost as one of the active ingredients, which is a first-choice treatment option for glaucoma
    •Combines two medications into a single eye drop for convenience
    •Convenient once-a-day dosing
    Cons
    •Can permanently darken the color of your eyes
    •No lower-cost generic available; brand-name medication only
    Pros and Const for Prostaglandin
    Pros
    •Might work better at lowering eye pressure than beta-blocker eye drops
    •Once-a-day eye drop
    •Can use with other eye pressure-lowering medications
    Cons
    •Can change the color of your eyes
    •No lower-cost generic available; brand-name medication only
    •Not recommended for children age 16 and younger because of possible permanent changes to eye color with long-term use

  • Common Side Effects of Rocklatan vs. Vyzulta

    Common Side Effects for
    •Eye redness (59%)
    •Eye pain after placing the drop into the eye (20%)
    •Corneal deposits (15%)
    •Red spot in the eye (popped blood vessel in the eye; 11%)
    Common Side Effects for
    •Red eyes (6%)
    •Eye irritation (4%)
    •Eye pain (3%)
    •Eye pain after placing the drop into the eye (2%)

  • Warnings of Rocklatan vs. Vyzulta

    Common Side Effects for
    •Darker eyes, eyelashes, or eyelids
    •Eyelash changes
    •Eye inflammation
    •Swelling of the retina (macular edema)
    •Risk for bacterial or viral eye infection when using contaminated medication
    •Don't use while wearing soft contact lenses
    Common Side Effects for
    •Darker eyes, eyelashes, or eyelids
    •Eyelash changes
    •Eye inflammation
    •Swelling of the retina (macular edema)
    •Risk for bacterial infection in the eye when using contaminated medication
    •Don't use while wearing soft contact lenses

  • Prices with our coupons for Rocklatan vs. Vyzulta

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