Key takeaways
Fenofibrate (Tricor, Trilipix) and atorvastatin (Lipitor) are both used to manage cholesterol levels, but they belong to different classes of medications and work in distinct ways. Fenofibrate is a fibrate that primarily lowers triglycerides and raises "good" cholesterol (HDL) by breaking down lipids in your blood. Atorvastatin, on the other hand, is a statin that lowers "bad" cholesterol (LDL) and triglycerides by blocking an enzyme in your liver that makes cholesterol. While both medications can be taken once daily, fenofibrate is available in various forms and brands, and its dosage may vary based on the specific formulation and your kidney function. Atorvastatin is available as a lower-cost generic and can be taken at any time of the day, with or without food. Both medications can cause serious side effects like liver problems and muscle damage, but atorvastatin also has a risk of raising blood sugar levels. Fenofibrate and atorvastatin are not recommended for use during pregnancy or breastfeeding. Both medications should be used with caution if you have liver problems, but Fenofibrate can also be problematic if you have gallbladder or severe kidney issues. Both medications require regular lab work to monitor their effects.
