Key takeaways
Theophylline (Theo-24, Elixophyllin, Theochron) and Breo Ellipta (fluticasone/vilanterol) are both used to help with breathing problems like asthma and COPD, but they work differently and have different uses. Theophylline is a nonselective PDE inhibitor that relaxes the muscles in your airways and helps strengthen your breathing muscles. It is taken orally and is not a first-choice medication because it requires regular blood tests and doesn't work as well as other options. Breo Ellipta, on the other hand, is an inhaled combination of an inhaled corticosteroid (ICS) and a long-acting beta agonist (LABA). It reduces inflammation and relaxes the muscles in your lungs. Breo Ellipta is typically taken once a day and is available in a lower-cost generic form. Unlike Theophylline, Breo Ellipta can start to improve breathing within 15 minutes but needs to be taken daily for the best results. Breo Ellipta should not be used during an asthma or COPD attack. Theophylline can cause side effects similar to having too much caffeine like a headache or trouble sleeping, while upper respiratory infections are common while taking Breo Ellipta. Additionally, Breo Ellipta requires you to rinse your mouth after use to prevent fungal infections, which is not a concern with Theophylline.
