Key takeaways
Simvastatin (Zocor) and Niacin ER (extended-release) are both used to manage cholesterol levels, but they work differently and have distinct uses. Simvastatin, a statin, is primarily used to lower "bad" LDL cholesterol and triglycerides while raising "good" HDL cholesterol. It works by blocking an enzyme in your liver that makes cholesterol. Niacin ER, also known as vitamin B3, is an antilipemic medication that lowers cholesterol by blocking the release of fat from fatty tissue and slowing down cholesterol production in the liver. Simvastatin is typically taken once daily in the evening, while Niacin ER is taken at bedtime after a low-fat snack. Simvastatin is a first-choice medication for lowering cholesterol, whereas Niacin ER is usually an add-on treatment for those who can't achieve their cholesterol goals with diet, exercise, or statins alone. Common side effects of Simvastatin include muscle pain and liver issues, while Niacin ER often causes flushing and stomach upset. Both medications are available in generic forms, making them more affordable options.
