Key takeaways
Quetiapine (Seroquel) and Latuda (lurasidone) are both atypical antipsychotics used to treat schizophrenia, bipolar disorder, and depression, but they have some key differences. Quetiapine is available in both immediate-release and extended-release forms, while Latuda is only available as a tablet taken once daily. Quetiapine can be used as an add-on treatment for depression in adults, whereas Latuda is specifically used for depression from bipolar disorder and can be combined with lithium or divalproex for this purpose. Quetiapine is more likely to cause weight gain and raise blood sugar and cholesterol levels, while Latuda has a lower risk of weight gain and may even lead to weight loss. Both medications can cause sleepiness, but quetiapine is also associated with a higher risk of agitation and dizziness. Additionally, both medications should be avoided in older adults with dementia-related psychosis due to a higher risk of death. Both medications are available as a low-cost generic.
