Key takeaways
Risperidone (Risperdal) and brexpiprazole (Rexulti) are both atypical antipsychotics, but they have some key differences. Risperidone is available in generic form and can be used to treat schizophrenia, bipolar disorder, and irritability associated with autism. In contrast, brexpiprazole (Rexulti) is available only as a brand-name medication and is approved for treating schizophrenia, as an add-on for depression, and for dementia-related agitation from Alzheimer's disease. Risperidone is typically taken once or twice daily, while brexpiprazole (Rexulti) is taken once daily. Common side effects of risperidone include sleepiness, movement problems, and weight gain, whereas brexpiprazole (Rexulti) may cause restlessness, dizziness, and headaches. Additionally, brexpiprazole (Rexulti) is less likely to cause weight gain, high cholesterol, or high blood sugar compared to risperidone. Brexpiprazole (Rexulti) can be more expensive and is not recommended for use during pregnancy.
