Skip to main content

Compare
Repatha vs. Crestor

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Repatha (evolocumab) and Crestor (rosuvastatin) are both medications used to treat high cholesterol and lower the risk of heart attack and stroke. However, they belong to different medication classes. Repatha is a PCSK9 inhibitor, which works by helping your body remove extra cholesterol from your blood, while Crestor is a statin that blocks the enzyme in your liver that makes cholesterol. Repatha is given as an injection every two weeks or once a month, whereas Crestor is taken as an oral tablet once a day. Repatha is only available as a brand-name medication, while Crestor is available in a lower-cost generic form. Common side effects of Repatha include cold- or flu-like symptoms and injection site reactions, while Crestor can cause muscle or joint pain and headaches. Crestor has many drug interactions and is not recommended during pregnancy.

Repatha

(evolocumab)

Get free coupons

Rosuvastatin

(Crestor)

Get free coupons

Summary for Repatha

Prescription only

Repatha (evolocumab) is a PCSK9 inhibitor that's given as an injection under the skin. It treats high cholesterol in adults and certain children. It works best with a heart-healthy diet and regular exercise. Repatha (evolocumab) also helps lower the risk of events like heart-related death, heart attack, and stroke in adults at risk. The medication is injected either once every 2 weeks or once a month. Side effects can include common cold symptoms and discomfort at the injection site.

Indications for Repatha

Pros and Cons for Repatha

Pros

  • Taken once every 2 weeks or once a month
  • Can use for inherited cholesterol conditions in kids 10 years and up
  • Has different injection devices to choose from (prefilled syringe, autoinjector, or on-body infusor)

Cons

  • Must give as an injection under the skin
  • Might cause reactions at the injection site like redness and pain
  • Caution use in people with a latex allergy for syringes and autoinjectors (some have parts made with natural rubber)

Common Side Effects for Repatha

Warnings for Repatha

  • Allergic reactions

Summary for Crestor

Prescription only

Rosuvastatin (Crestor) is a statin. It's used to treat high cholesterol levels in adults and children. It can also help lower the risk heart attack or stroke in people who are at risk for heart-related problems. Rosuvastatin (Crestor) comes as both generic and brand name tablets that are taken by mouth, typically once daily. Brand name Ezallor Sprinkle (rosuvastatin) is an option for people who've trouble swallowing pills. Common side effects of rosuvastatin (Crestor) include muscle pain, joint pain, and headache.

Indications for Crestor

Pros and Cons for Crestor

Pros

  • First-choice cholesterol medication that lowers your risk of heart attack and stroke
  • Can be taken by children as young as 7 years old
  • Sprinkle capsule (Ezallor Sprinkle) can be opened and contents sprinkled over soft food
  • Available as a lower cost, generic form

Cons

  • Not safe to take for people who are pregnant or breastfeeding
  • Might lead to liver problems
  • Can cause rhabdomyolysis, a life-threatening muscle problem
  • Might raise blood sugar levels, especially in people who have pre-diabetes

Common Side Effects for Crestor

  • Muscle pain (8-13%)
  • Joint pain (4-10%)
  • Headache (6-9%)
  • Nausea (2-6%)
  • Constipation (up to 5%)

Warnings for Crestor

  • Severe muscle pain and damage
  • Liver problems
  • Higher blood sugar levels
  • Possible harm during pregnancy or breastfeeding

Prices with our coupons for Repatha vs. Crestor

Price Card Drug Icon
Repatha2 sureclicks / 1ml of 140mg/ml
$239.00$691.01
Get free coupons
More Information
Price Card Drug Icon
Rosuvastatin30 tablets / 20mg
$11.36$92.57
Get free coupons
More Information

Compare other High Cholesterol drugs

Nexletol vs. RepathaRepatha vs. CrestorRepatha vs. PraluentCrestor vs. PravastatinLipitor vs. Vytorin
Lipitor vs. ZetiaNexletol vs. NexlizetNiaspan vs. CrestorNiaspan vs. Omega-3-acidNiaspan vs. TrilipixNiaspan vs. VytorinOmega-3-acid vs. AtorvastatinOmega-3-acid vs. CrestorOmega-3-acid vs. LopidPravastatin vs. AntaraPravastatin vs. AtorvastatinPravastatin vs. LivaloPravastatin vs. LopidPravastatin vs. RosuvastatinTrilipix vs. AtorvastatinTrilipix vs. CrestorTrilipix vs. LopidTrilipix vs. Omega-3-acidTrilipix vs. VytorinVytorin vs. AtorvastatinVytorin vs. CrestorVytorin vs. LopidZetia vs. CrestorZetia vs. VytorinZocor vs. Trilipix

Browse medications by letter

Show All

Browse prescription and over-the-counter medications from A to Z, compare drug prices, and start saving.