Key takeaways
Nabumetone (Relafen) and ibuprofen (Advil, Motrin) are both nonsteroidal anti-inflammatory drugs (NSAIDs) used to relieve pain and inflammation. However, there are some key differences between them. Nabumetone is available only by prescription, while ibuprofen can be purchased over-the-counter or by prescription, depending on the strength. Nabumetone is typically taken once or twice a day, which can be more convenient compared to ibuprofen, which usually needs to be taken every 4 to 8 hours. Nabumetone is noted for causing fewer stomach-related side effects than ibuprofen, making it a potentially better option for those with sensitive stomachs. On the other hand, ibuprofen is more versatile, being used for a wider range of conditions such as headaches, muscle aches, and fever, in addition to arthritis pain. Both medications carry risks of serious side effects like stomach bleeding, heart attack, and kidney problems, but nabumetone has additional warnings for long-term use and specific heart conditions. Always consult a healthcare professional to determine which medication is best for your needs.
