Key takeaways
Nabumetone (Relafen) and celecoxib (Celebrex) are both prescription medications used to treat arthritis pain and inflammation, but they have some key differences. Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) that is typically taken once or twice a day and is known for causing fewer stomach-related side effects compared to some other NSAIDs. Celecoxib, on the other hand, is a COX-2 selective NSAID, which means it specifically targets the COX-2 enzyme involved in pain and swelling, leading to a lower risk of stomach bleeding and ulcers. Celecoxib can be taken once or twice a day and is also approved for additional conditions like juvenile rheumatoid arthritis and menstrual cramps, which nabumetone is not. While both medications can increase the risk of heart attack and stroke, celecoxib has a specific warning for people with sulfa allergies. Additionally, celecoxib is available in a generic form, making it a potentially more affordable option. Both medications should be taken with caution, especially if you have a history of heart disease, stomach issues, or are pregnant.
