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Provigil vs. AndroGel

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Modafinil (Provigil) and testosterone gel (Testim, AndroGel, Fortesta, Vogelxo) are both prescription medications, but they serve very different purposes. Modafinil is a wakefulness-promoting agent used to treat excessive sleepiness due to conditions like narcolepsy, obstructive sleep apnea, or shift work disorder. It is taken orally once a day and is a Schedule IV controlled substance due to its potential for misuse. Common side effects include headache and nausea. On the other hand, testosterone gel is used to treat low testosterone levels in adult males and is applied topically once a day. It is a Schedule III controlled substance and carries risks of skin irritation and accidental transfer to others through skin contact. While modafinil affects the central nervous system to promote wakefulness, testosterone gel works by replacing or supplementing the natural hormone in the body. Both medications have serious side effects and risks, including heart problems for modafinil and potential for misuse and dependency for testosterone gel.

Modafinil

(Provigil)

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testosterone gel

 

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Summary for Provigil

Prescription only

Modafinil (Provigil) helps improve wakefulness in adults with narcolepsy, obstructive sleep apnea, or shift work disorder. This wake-promoting medication comes as a tablet that’s taken by mouth. For adults with narcolepsy or sleep apnea, you take a dosage once daily in the morning. And for those with shift work disorder, you take your dosage 1 hour before the start of your work shift. Common side effects include headache and nausea. Modafinil (Provigil) is a controlled substance because of its potential for misuse.

Indications for Provigil

Pros and Cons for Provigil

Pros

Cons

Common Side Effects for Provigil

  • Headache (34%)
  • Nausea (11%)
  • Feeling nervous (7%)
  • Runny nose (7%)
  • Back pain (6%)
  • Diarrhea (6%)
  • Anxiety (5%)
  • Dizziness (5%)
  • Indigestion (5%)
  • Trouble sleeping (5%)

Warnings for Provigil

  • Serious allergic reactions
  • Serious rash and skin reactions
  • Sleepiness and trouble focusing, thinking, and reacting
  • Unusual changes in mood and behavior
  • Heart problems
  • Changes in blood pressure and heart rate

Summary for AndroGel

Prescription only

Testosterone gel is a prescription topical medication used to treat men with low testosterone. It helps raise testosterone levels when your body doesn't make enough naturally. You typically apply it once a day to your skin. Depending on the product, the gel comes in packets, pumps, or tubes. Some side effects include skin irritation, mood changes, and headache.

Note: This medication is available under several brand names, including AndroGel, Testim, and Vogelxo as well as in generic versions. Each might have different strengths, application sites, and instructions.

Indications for AndroGel

Pros and Cons for AndroGel

Pros

  • Works well to raise testosterone levels
  • Applied once a day to your skin
  • Available in tubes, packets, or as a pump

Cons

  • Can cause skin irritation
  • Must avoid skin-to-skin transfer to other people
  • Need to wait hours before you can shower, swim, or bathe

Common Side Effects for AndroGel

AndroGel 1.62%

AndroGel 1%

  • Acne (1-8%)
  • Abnormal lab tests (3-6%)
  • Skin irritation (3-5%)
  • Prostate problems (3-5%)

Testim

  • Skin irritation (2-4%)
  • Rise in red blood cell count (1-2%)

Vogelxo

  • Skin irritation (2-4%)
  • Rise in red blood cell count (1-2%)

Warnings for AndroGel

  • Risk of testosterone gel spreading to others
  • Higher red blood cell count
  • Blood clots
  • Worsening of enlarged prostate and risk of prostate cancer
  • Higher blood pressure
  • Potential for misuse, addiction, and dependency
  • Lower sperm count
  • Liver problems
  • Swelling in the arms and legs (edema)
  • Enlarged breasts
  • Breathing problems during sleep (sleep apnea)
  • Changes in cholesterol levels
  • High calcium levels

Prices with our coupons for Provigil vs. AndroGel

Price Card Drug Icon
Modafinil30 tablets / 200mg
$22.28$136.82
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Testosterone1 pump / 88g of 1.62%
$39.70$411.35
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