Key takeaways
Desvenlafaxine (Pristiq) and trazodone (Raldesy) are both medications used to treat depression in adults, but they belong to different medication classes. Desvenlafaxine is a serotonin and norepinephrine reuptake inhibitor (SNRI), while trazodone is an atypical antidepressant known as a serotonin antagonist and reuptake inhibitor (SARI). Desvenlafaxine is typically taken once a day, whereas trazodone can be taken in divided doses throughout the day. Trazodone is sometimes used off-label for insomnia, but desvenlafaxine is not. Both medications are available as brand-name and lower-cost generic products. Common side effects of desvenlafaxine include nausea and dizziness, while trazodone often causes sleepiness and dry mouth. Both medications can interact with other drugs that affect serotonin levels, increasing the risk of serotonin syndrome. Desvenlafaxine can raise blood pressure, while trazodone can cause low blood pressure and affect heart rhythm. Always talk to a healthcare professional about any concerns or side effects you experience with these medications.
