Key takeaways
Lisinopril (Zestril) and Zestoretic (lisinopril / hydrochlorothiazide) are both medications used to treat high blood pressure. They both contain lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, which helps relax blood vessels. However, Zestoretic is a combination medication that also includes hydrochlorothiazide, a diuretic or "water pill" that helps remove extra water and certain electrolytes from your body. Lisinopril is available as a tablet and an oral solution, while Zestoretic is only available as a tablet. Both medications are taken once daily, but Zestoretic may cause you to urinate more often due to the diuretic component. Common side effects of both include dizziness, headache, and cough, but Zestoretic can also cause tiredness and changes in electrolyte levels. Both medications should not be used during pregnancy and can interact with other medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs). If you experience any severe side effects like swelling or difficulty breathing, you should contact your prescriber immediately.
