Key takeaways
Captopril (Capoten) and perindopril (Aceon) are both ACE inhibitor medications used to treat high blood pressure and certain heart-related conditions, including lowering the risk of heart attack. Captopril is taken two to three times a day on an empty stomach, while perindopril is usually taken once a day. Both medications are available as a lower-cost generic. Side effects of both medications include a dry cough and dizziness, and both may rarely cause angioedema. Both medications can interact with NSAIDs like ibuprofen (Motrin) and naproxen (Aleve) and are not recommended during pregnancy.
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