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Compare Prezista vs. Genvoya

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Prezista (darunavir) and Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) are both used to treat HIV infections, but they have some key differences. Prezista is a protease inhibitor that needs to be taken with a booster like ritonavir (Norvir) and food, while Genvoya is a combination of four medications, including two NRTIs, an INSTI, and a booster, and also needs to be taken with food. Prezista is available as an oral tablet or suspension, making it easier for those who have trouble swallowing pills, whereas Genvoya is only available as a tablet. Prezista can be used during pregnancy, but Genvoya cannot. Additionally, Prezista requires regular blood tests to monitor liver health, especially in those with hepatitis B or C, while Genvoya can worsen hepatitis B if stopped suddenly. Both medications have common side effects like nausea and diarrhea, but Prezista also has a risk of severe skin reactions and changes in body fat distribution. Genvoya, on the other hand, can cause kidney problems and lactic acidosis. Lastly, Prezista has a generic form, while Genvoya does not.

  • Prezista (darunavir)
    Genvoya
  • Prezista (darunavir)
    Genvoya

  • Summary of Prezista vs. Genvoya

    Summary for HIV ARV
    Prescription only

    Prezista (darunavir) is an oral tablet or suspension that's used as part of an antiretroviral (ARV) regimen to treat human immunodeficiency virus (HIV) infections. It's often taken in combination with a "booster," like ritonavir (Norvir), to help Prezista (darunavir) work better against the virus. Rarely, this medication can cause a skin rash within the first month of treatment, but it typically goes away on its own. Lastly, let your provider know if you have a history of sulfa allergy since Prezista (darunavir) contains a "sulfa" component.

    Summary for HIV ARV combo
    Prescription only

    Genvoya (elvitegravir / cobicistat / emtricitabine / tenofovir alafenamide) is a combination antiretroviral therapy (ART) that treats human immunodeficiency virus (HIV) infections in adults and children. It's made up of two nucleoside reverse transcriptase inhibitors (NRTIs), emtricitabine and tenofovir alafenamide; an integrase strand transfer inhibitor (INSTI) called elvitegravir; and a "booster" medication known as cobicistat. Genvoya is taken by mouth, typically once daily. Some common side effects of this medication include nausea and diarrhea. It's not available as a generic medication.

  • Indications of Prezista vs. Genvoya

    Indications for
    •Treatment of HIV infection in people aged 3 years and older
    Indications for
    •Treatment of HIV infection

  • Pros and Cons of Prezista vs. Genvoya

    Pros and Const for HIV ARV
    Pros
    •Taken once a day by mouth
    •Available as an oral suspension, so it's convenient if you have trouble swallowing pills
    •Safe to take during pregnancy
    Cons
    •Requires regular blood work and lab tests
    •Interacts with many medications
    •Must be used carefully in people with sulfa allergies
    Pros and Const for HIV ARV combo
    Pros
    •Is a complete regimen for HIV treatment
    •Only taken once a day
    •Taken by mouth
    Cons
    •Needs to be taken with food
    •Can’t take while pregnant
    •Can worsen hepatitis B if you stop taking the medication all of a sudden

  • Common Side Effects of Prezista vs. Genvoya

    Common Side Effects for
    •Diarrhea (9-14%)
    •Rash (6-7%)
    •Nausea (4-7%)
    •Headache (3-7%)
    •Stomach pain (6%)
    •Vomiting (2-5%)

    Side effects above were reported in adults taking this medication with ritonavir (Norvir). Side effects might differ in children.

    Common Side Effects for
    •Nausea (11%)
    •Diarrhea (7%)
    •Headache (6%)
    •Feeling tired (5%)

  • Warnings of Prezista vs. Genvoya

    Common Side Effects for
    •Liver problems
    •Severe skin and allergic reactions
    •Changes in body fat
    •Overactive immune system
    •Bleeding
    •Interactions with other medications
    Common Side Effects for
    •Worsening of hepatitis B infection
    •Kidney problems
    •Liver problems and lactic acidosis
    •Overactive immune system
    •Interaction with other medications

  • Prices with our coupons for Prezista vs. Genvoya

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    Learn more about Genvoya

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