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Polytrim vs. Quixin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Polytrim (polymyxin B / trimethoprim) and Quixin (levofloxacin) are both antibiotic eye drops used to treat bacterial eye infections, but they have some key differences. Polytrim is a combination of two antibiotics, polymyxin B and trimethoprim, and is used for mild-to-moderate infections in adults and children as young as 2 months. It needs to be applied every 3 hours, up to 6 times a day, for 7 to 10 days. On the other hand, Quixin contains levofloxacin, a fluoroquinolone antibiotic, and is used for bacterial conjunctivitis and corneal ulcers. Quixin has different dosing schedules depending on the strength: the 0.5% strength is used for pink eye and the 1.5% strength for corneal ulcers, with more frequent applications initially. Both medications are available as a lower-cost generic. Both medications can cause temporary eye irritation, but Quixin may also cause headaches and changes in taste. Additionally, Polytrim is safe for use in younger children, whereas Quixin is recommended for children 6 years and older.

Polytrim

(polymyxin B / trimethoprim)

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Levofloxacin

(eye drop)

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Summary for Polytrim

Prescription only

Polytrim (polymyxin B / trimethoprim) is a combination antibiotic eye drop. It's used to treat mild-to-moderate bacterial eye infections, such as pink eye, in adults and children ages 2 months and older. The typical dose is 1 drop applied directly in the eye(s) every 3 hours for 7 to 10 days. Some of the more common side effects of this eye drop include symptoms of eye irritation, such as redness, stinging, and itching. Polytrim (polymyxin B / trimethoprim) is available as a lower-cost generic.

Indications for Polytrim

  • Mild-to-moderate infections on the eye and eyelid

Pros and Cons for Polytrim

Pros

  • Can treat a variety of eye infections in adults and children
  • Available as a lower-cost generic
  • Applied directly on the eyes, so it has less side effects than oral antibiotics

Cons

  • Has to be used every 3 hours for at least a week
  • Can cause temporary eye irritation after applying
  • Can make your eyes more sensitive to light

Common Side Effects for Polytrim

  • Eye irritation (e.g., redness, burning, stinging, itching)

Warnings for Polytrim

  • For use in the eye only
  • New infection
  • Damage to contact lenses (when used in the eye)

Summary for Quixin

Prescription only

Levofloxacin (eye drop) is an antibiotic eye drop that's used to treat pink eye (0.5% strength) or corneal ulcers (1.5% strength) caused by bacteria. You shouldn't use it for more than a few days to treat the infection. And you'll need to use it multiple times a day for it to work.

Indications for Quixin

  • Bacterial conjunctivitis (pink eye) - 0.5% strength
  • Corneal ulcer - 1.5% strength

Pros and Cons for Quixin

Pros

  • Applied directly where the infection is
  • Causes fewer serious side effects than oral antibiotics
  • Safe to use in children 6 years and older

Cons

  • Has to be used multiple times a day
  • Can cause temporary eye irritation after applying
  • Might be difficult to administer for some people

Common Side Effects for Quixin

Levofloxacin (eye drop) 0.5% strength:

  • Temporary eye burning, pain, or discomfort (1-3%)
  • Temporary blurry or loss of vision (1-3%)
  • Headache (1-3%)

Levofloxacin (eye drop) 1.5% strength:

  • Headache (8-10%)
  • Change in taste (8-10%)

Warnings for Quixin

  • Severe allergic reactions
  • New infection if used too long

Prices with our coupons for Polytrim vs. Quixin

Price Card Drug Icon
Polymyxin B/Trimethoprim1 eye dropper / 10ml of 10000units/1mg/ml
$10.46$12.02
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Price Card Drug Icon
Levofloxacin1 eye dropper / 5ml of 0.5%
$52.00$65.59
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