Key takeaways
Paroxetine (Paxil) and nefazodone are both used to treat depression, but they have some key differences. Paroxetine, also known by its brand name Paxil, is a selective serotonin reuptake inhibitor (SSRI) that also treats various anxiety disorders. It is available in both brand and generic forms and comes in immediate-release and extended-release tablets, as well as an oral suspension. Common side effects include nausea, sexual problems, and weight gain, and it can cause withdrawal symptoms if stopped suddenly. On the other hand, nefazodone is an atypical antidepressant that raises serotonin and norepinephrine levels. It is only available as a generic since the brand name Serzone has been discontinued. Nefazodone typically does not cause weight changes and is taken twice daily. Both medications can worsen depression and increase the risk of suicidal thoughts, especially in younger people. However, nefazodone has a risk of liver failure, making it less commonly prescribed.
