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Pantoprazole vs. Calcium carbonate/magnesium hydroxide

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Pantoprazole (Protonix) and Rolaids (calcium carbonate/magnesium hydroxide) are both used to treat stomach issues, but they work differently and are used for different purposes. Pantoprazole is a prescription-only proton pump inhibitor (PPI) that reduces stomach acid production and is used for conditions like GERD and erosive esophagitis. It is taken once daily and can have side effects like headache and diarrhea. On the other hand, Rolaids is an over-the-counter antacid that provides quick relief for heartburn and indigestion by neutralizing stomach acid. Rolaids can be taken as needed throughout the day but should not be used at maximum dosage for more than two weeks. Unlike pantoprazole, Rolaids is not meant for long-term use and can interact with the absorption of other medications. While pantoprazole is available in various forms including tablets and injections, Rolaids comes in chewable tablets and soft chews.

Pantoprazole

(Protonix)

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Rolaids

 

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Summary for Pantoprazole

Prescription only

Pantoprazole (Protonix) is a proton-pump inhibitor (PPI). It's used to treat symptoms of gastroesophageal reflux disease (GERD) in adults and children. It's also used to treat other conditions involving too much stomach acid, such as erosive esophagitis, in adults only. Pantoprazole (Protonix) is taken by mouth, typically once daily for most conditions. Some of the more common side effects of this medication include headache and diarrhea. Pantoprazole (Protonix) isn't available over-the-counter (OTC).

Indications for Pantoprazole

Pros and Cons for Pantoprazole

Pros

  • Can continue to use with antacids, such as calcium carbonate
  • Available as a lower-cost generic medication
  • Oral tablets can be taken without regard to food
  • Available in oral granules and suspension for people with trouble swallowing

Cons

  • Long-term use might weaken bones and raise the risk of bone fractures
  • Might cause or worsen lupus
  • Interacts with warfarin (Coumadin), which can raise the risk of bleeding
  • Not available over-the-counter

Common Side Effects for Pantoprazole

  • Headache (12%)
  • Diarrhea (9%)
  • Nausea (7%)
  • Belly pain (6%)

Please note: Side effect percentages are listed for adults with GERD.

Warnings for Pantoprazole

  • Risk of hiding symptoms of a more serious problem
  • Sudden kidney problems
  • Severe infectious diarrhea
  • Bone fractures
  • Skin reactions
  • Lupus
  • Low vitamin B12 and magnesium levels
  • Interaction with other medications
  • Inaccurate lab work

Summary for Calcium carbonate/magnesium hydroxide

Over-the-counter

Rolaids is a combination medication containing calcium and magnesium. It provides fast symptom relief for heartburn and indigestion.

Indications for Calcium carbonate/magnesium hydroxide

  • Heartburn
  • Indigestion
  • Relief of sour stomach

Pros and Cons for Calcium carbonate/magnesium hydroxide

Pros

  • Provides fast relief for heartburn and indigestion
  • Can buy over the counter (OTC), without a prescription
  • There are tablets and soft chews in a variety of flavors (Rolaids brand)

Cons

  • Doesn't last as long as other heartburn medications, like famotidine (Pepcid) and omeprazole (Prilosec)
  • Not meant for long-term use
  • Interacts with the absorption of some other medications, such as certain antibiotics

Common Side Effects for Calcium carbonate/magnesium hydroxide

See Risks and Warnings

Warnings for Calcium carbonate/magnesium hydroxide

  • Medication interactions
  • High blood calcium

Prices with our coupons for Pantoprazole vs. Calcium carbonate/magnesium hydroxide

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Pantoprazole30 tablets / 40mg
$9.87$16.47
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Price Card Drug Icon
Calcium Carbonate/Magnesium Hydroxide30 chewable tablets / 675mg/135mg
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