Key takeaways
Trazodone and temazepam (Restoril) are both medications used to help with sleep, but they work differently. Trazodone is an atypical antidepressant that is sometimes used off-label for insomnia, while temazepam is a benzodiazepine specifically approved for short-term treatment of insomnia. Trazodone affects serotonin levels in the brain and is not a controlled substance, meaning it does not carry a risk of addiction. In contrast, temazepam works by slowing down brain activity through GABA receptors and is a Schedule IV controlled substance due to its potential for misuse and addiction. Trazodone can be taken multiple times a day for depression or once at bedtime for sleep, but temazepam is only taken once at bedtime for sleep. Trazodone is generally considered safer for long-term use, whereas temazepam should only be used short-term for up to 10 days. Both medications can cause drowsiness and dizziness, but temazepam has additional risks like memory problems and complex behaviors such as sleepwalking.
