Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Cyclobenzaprine (Flexeril) and diazepam (Valium) are both used to treat muscle spasms, but they belong to different medication classes and have distinct uses and side effects. Cyclobenzaprine is a muscle relaxant that works in the brain to relieve muscle pain and discomfort, and it is available in both immediate-release and extended-release forms. It is not a controlled substance but can cause drowsiness and dizziness, especially when combined with alcohol. Diazepam, on the other hand, is a benzodiazepine that raises levels of GABA in the brain to help with anxiety, alcohol withdrawal, muscle spasms, and seizures. It is a Schedule IV controlled substance due to its potential for misuse and dependence. Diazepam can also cause sleepiness, dizziness, and muscle weakness, and it carries risks of severe sedation and withdrawal symptoms if stopped abruptly. While both medications can make you sleepy, diazepam has a higher risk of dependence and is generally not recommended during pregnancy or breastfeeding.
Cyclobenzaprine is a muscle relaxant used in addition to rest and physical therapy to treat muscle pain and discomfort. It's available as an immediate-release (IR) tablet and an extended-release (ER) capsule. Unlike other muscle relaxants, it's not considered a controlled substance. Cyclobenzaprine can make you sleepy as a side effect so it's best to avoid alcohol to prevent serious harm from combining the two together.
Diazepam (Valium) is a benzodiazepine. It's used to treat symptoms of anxiety and alcohol withdrawal. It can also treat certain types of muscle spasms and seizures. Diazepam (Valium) comes as a tablet and liquid solution. It's taken by mouth, typically 2 to 4 times daily. Some common side effects of diazepam (Valium) include sleepiness, dizziness, and weakness. Additionally, this medication carries a risk for misuse and dependence, so it's classified as a controlled substance.
Immediate-release tablets:
Extended-release capsules:
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