Carisoprodol (Soma) and orphenadrine (formerly branded as Norflex) are both muscle relaxants used to treat muscle pain and discomfort, but they have some key differences. Carisoprodol is a controlled substance due to its potential for misuse and dependence, while orphenadrine is not a controlled medication. Carisoprodol is typically taken four times a day and is only recommended for short-term use (up to 2 to 3 weeks), whereas orphenadrine is taken twice a day and can be administered orally or by injection. Orphenadrine is only available as a generic medication, while carisoprodol is available in generic and brand forms. Common side effects of carisoprodol include drowsiness, dizziness, and headaches, while orphenadrine can cause dry mouth, sleepiness, and headaches. Additionally, orphenadrine is not recommended for older adults and people with certain conditions like glaucoma or stomach ulcers, whereas carisoprodol has a broader range of use but comes with a higher risk of dependence and withdrawal symptoms.