Key takeaways
Gablofen (baclofen) and orphenadrine ER (Norflex) are both muscle relaxants, but they have different uses and methods of administration. Gablofen (baclofen) is used to treat severe spasticity in people who can't tolerate or don't get enough relief from oral baclofen. It's given as a continuous infusion through an implantable pump directly into the space around the spinal cord. On the other hand, orphenadrine ER is used to relieve muscle pain and discomfort from short-term muscle conditions and is taken orally. Gablofen (baclofen) is typically for long-term use and requires surgical implantation and regular refills by a healthcare professional, while orphenadrine ER is taken by twice a day. Gablofen (baclofen) different side effects compared to oral muscle relaxers like orphenadrine ER, which can cause dry mouth, headache, and drowsiness. Both drugs are available as lower-cost generics.
