Key takeaways
Metaxalone (Skelaxin) and Orphengesic Forte (orphenadrine/aspirin/caffeine) are both used to relieve muscle pain, but they have some key differences. Metaxalone is a muscle relaxant that works by relaxing your nervous system in the brain and is typically taken three to four times a day. It is available as a lower-cost generic and is not a controlled substance. Orphengesic Forte, on the other hand, is a combination medication that includes a muscle relaxant (orphenadrine), an NSAID (aspirin), and caffeine. It is used for muscle, bone, joint, or tendon pain and also needs to be taken multiple times a day. Orphengesic Forte carries more serious risks, such as stomach bleeding and ulcers due to the aspirin component, and it is not recommended for use in children or pregnant women after 20 weeks. Additionally, you need to limit caffeine intake while taking Orphengesic Forte. Both medications can cause drowsiness and dizziness, but Orphengesic Forte has a broader range of potential side effects and interactions due to its combination of ingredients.
