Key takeaways
Odefsey (emtricitabine/rilpivirine/tenofovir alafenamide) and Truvada (emtricitabine/tenofovir disoproxil fumarate) are both used to treat HIV, but they have some key differences. Odefsey is a single-tablet regimen that includes three medications, while Truvada contains only two and must be taken with another HIV medication for a complete treatment. Odefsey must be taken with a meal, whereas Truvada can be taken with or without food. Truvada is also approved for HIV prevention (PrEP), making it a versatile option for those at risk of infection. Odefsey is considered safer for your kidneys and bones compared to Truvada, which is more likely to cause bone problems. Both medications require regular blood tests to monitor your health, but Odefsey has more medication interactions and specific meal requirements. Truvada is available as a lower-cost generic, while Odefsey does not have a generic form.
