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Novolin R vs. Humulin R

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Novolin R

 

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Humulin R

(insulin regular)

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Summary for Novolin R

Prescription or over-the-counter

Novolin R is a short-acting insulin. It's used to control blood glucose (sugar) levels in adults and children with Type 1 or Type 2 diabetes. For the multi-dose vials of Novolin R, you'll need to draw up the dose into a syringe. Single-use prefilled pens called Novolin R FlexPen are also available for easier use. Novolin R is typically injected under the skin 2 to 3 times a day, 30 minutes before a meal. Some common side effects include low blood sugar levels and injection-site redness or pain.

Indications for Novolin R

Pros and Cons for Novolin R

Pros

  • Available over the counter without a prescription
  • Can help manage either Type 1 or Type 2 diabetes
  • Available as a pen and vial

Cons

  • Need multiple injections per day, each time before a meal
  • Can cause weight gain and low blood sugar
  • Must check your blood sugar at home often

Common Side Effects for Novolin R

Warnings for Novolin R

  • Risk of infections from sharing injection supplies
  • Risk of changes to blood sugar levels with changes to your insulin regimen
  • Low blood sugar levels (hypoglycemia)
  • Low potassium levels
  • Swelling and risk of heart failure when using with certain diabetes medications
  • Severe allergic reaction

Summary for Humulin R

Prescription or over-the-counter

Humulin R (insulin regular) is a short-acting insulin. It's used to control blood glucose (sugar) levels in adults and children with Type 1 diabetes (T1D) or Type 2 diabetes (T2D). Humulin R (insulin regular) is typically injected under the skin 2 to 3 times daily 30 minutes before meals. Some common side effects of Humulin R (insulin regular) include low blood sugar levels (hypoglycemia) and injection-site redness or pain. Humulin R (insulin regular) is available in two different strengths: U-100 (100 units/mL) and U-500 (500 units/mL). Both strengths come as vials, but the U-500 also comes as a prefilled pen.

Note: Humulin R U-500 is prescription only; Humulin R U-100 is available both OTC and by prescription.

Indications for Humulin R

Pros and Cons for Humulin R

Pros

  • Can help manage both Type 1 and Type 2 diabetes
  • Available over the counter without a prescription (Humulin R U-100 only)
  • Comes as pen and vial (Humulin R U-500 only)

Cons

  • Might cause weight gain
  • Risk of dangerously low blood sugar levels
  • Given as injection

Common Side Effects for Humulin R

  • Low blood sugar
  • Reactions where the medication is injected (e.g., redness, swelling, itching)

Warnings for Humulin R

  • Risk of infections from sharing injection supplies
  • Risk of changes to blood sugar levels with changes to your insulin regimen
  • Dangerously low blood sugar levels (hypoglycemia)
  • Low blood potassium levels
  • Swelling and heart failure
  • Severe allergic reactions

Prices with our coupons for Novolin R vs. Humulin R

Price Card Drug Icon
Novolin R1 vial / 10ml of 100 units/ml
$52.52$138.30
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Price Card Drug Icon
Humulin R1 vial / 10ml of 100 units/ml
$50.31$163.53
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