Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Humulin R (insulin regular) and Novolin R (insulin regular) are both short-acting insulins used to manage blood sugar levels in people with type 1 and type 2 diabetes. They start working in about 30 minutes and last for several hours. Both medications are available over the counter and can be used with other diabetes medications like metformin. However, Humulin R has a unique, more concentrated form called Humulin R U-500, which is available by prescription only and is meant for those who need large doses of insulin. Novolin R is not available as a concentrated version. Both insulins come in pens and vials, but their storage instructions differ slightly. For example, opened Novolin R vials can be stored at room temperature for up to 42 days, while Humulin R vials can be stored for 31 days. Both medications require careful monitoring of blood sugar levels and proper injection techniques to avoid complications like low blood sugar and infections.
Humulin r (insulin regular)
Novolin r
Humulin r (insulin regular)
Novolin r
Summary of Humulin R vs. Novolin R
Summary for Insulin
Humulin R (insulin regular) is a short-acting insulin. It's used to control blood glucose (sugar) levels in adults and children with Type 1 diabetes (T1D) or Type 2 diabetes (T2D). Humulin R (insulin regular) is typically injected under the skin 2 to 3 times daily 30 minutes before meals. Some common side effects of Humulin R (insulin regular) include low blood sugar levels (hypoglycemia) and injection-site redness or pain. Humulin R (insulin regular) is available in two different strengths: U-100 (100 units/mL) and U-500 (500 units/mL). Both strengths come as vials, but the U-500 also comes as a prefilled pen.
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Note: Humulin R U-500 is prescription only; Humulin R U-100 is available both OTC and by prescription.
Summary for Insulin
Novolin R is a type of insulin used to control blood sugar for many hours during the day, but it might take time to find the right dose that works for you. This medication is available over the counter without a prescription.