Key takeaways
Climara (estradiol) and Estrace (estradiol) are both estrogen replacement therapies, but they are used differently and treat different symptoms. Climara is a transdermal patch applied to the skin once or twice a week, primarily used to relieve multiple menopause symptoms like hot flashes and vaginal dryness, and to prevent osteoporosis. In contrast, Estrace is a vaginal cream applied directly to the vagina, used specifically to treat vaginal symptoms such as itching, dryness, and burning due to menopause. Climara can cause weight gain, while Estrace generally has fewer systemic side effects because it is applied locally. Both Climara and Estrace have a risk of serious side effects like blood clots and certain cancers, especially if you have a uterus and don't use either medication with progestin. Both medications require a prescription and have generic forms available, making them more affordable.
