Key takeaways
Lunesta (eszopiclone) and Rozerem (ramelteon) are both used to treat insomnia, but they work in different ways and have distinct characteristics. Lunesta is a sedative-hypnotic that may interact with GABA proteins in the brain to help you feel calmer and sleepier. It is a controlled substance (Schedule IV) and can be habit-forming, with potential side effects like a bad taste in your mouth, headache, and abnormal sleep behaviors such as sleepwalking. On the other hand, Rozerem is a melatonin receptor agonist that mimics the natural hormone melatonin to regulate your sleep cycle. It is not a controlled substance and is not known to be habit-forming. Rozerem should be taken on an empty stomach and can cause side effects like dizziness and fatigue. Unlike Lunesta, Rozerem can cause hormonal changes and is not recommended for people with sleep apnea or severe liver problems. Both medications are available in generic forms, making them more affordable options for treating insomnia.
