Key takeaways
Gemfibrozil (Lopid) and fenofibrate (Tricor, Trilipix) are both fibrates used to lower triglycerides and bad cholesterol (LDL) while raising good cholesterol (HDL). However, there are some key differences between the two. Gemfibrozil is typically taken twice a day before meals, while fenofibrate is taken once a day and can be taken with or without food, depending on the brand. Fenofibrate is preferred if you are already taking a statin because it has a lower risk of muscle problems compared to gemfibrozil. Both medications can cause muscle damage, but fenofibrate also has a higher risk of liver damage and blood clots. Additionally, fenofibrate comes in various forms, including tablets and capsules, and is available under multiple brand names and as a generic. Gemfibrozil is only available as a tablet. Both medications require you to follow a healthy diet and limit or avoid alcohol to get the best results.
