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Lexapro vs. Lyrica

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lexapro (escitalopram) and Lyrica (pregabalin) are both prescription medications, but they are used for different conditions and belong to different drug classes. Lexapro is an SSRI (selective serotonin reuptake inhibitor) primarily used to treat depression and generalized anxiety disorder (GAD). It works by increasing serotonin levels in the brain and is typically taken once daily. On the other hand, Lyrica is an antiepileptic medication used to treat nerve pain from conditions like diabetes, shingles, and spinal cord injury, as well as fibromyalgia and partial-onset seizures. Lyrica is usually taken two or three times a day. Lexapro is not a controlled substance, while Lyrica is classified as a Schedule V controlled substance due to its potential for addiction and dependence. Common side effects of Lexapro include nausea, trouble sleeping, and drowsiness, whereas Lyrica often causes dizziness, drowsiness, and weight gain. Additionally, Lexapro is available in both tablet and liquid forms, while Lyrica comes as a capsule and oral solution.

Escitalopram

(Lexapro)

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Pregabalin

(Lyrica)

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Summary for Lexapro

Prescription only

Escitalopram, also known by its brand name, Lexapro, is a selective serotonin reuptake inhibitor (SSRI). It's a first-choice antidepressant to treat depression and anxiety in adults and children. The medication is available as a tablet and oral solution, in both brand and generic forms. A dose is typically taken by mouth once per day. Some common side effects include nausea, trouble sleeping (insomnia), and dizziness.

Indications for Lexapro

Pros and Cons for Lexapro

Pros

  • First-choice medication for anxiety and depression
  • Only need to take it once a day
  • Generally has fewer side effects compared to other antidepressants
  • Can be taken with or without food

Cons

  • Can take up to 2 months before you feel the the full benefits
  • Risk of certain sexual problems
  • Can raise your risk for bleeds
  • Can cause withdrawal symptoms if you suddenly stop taking it

Common Side Effects for Lexapro

  • Headache (24%)
  • Nausea (15-18%)
  • Ejaculation problems (9-14%)
  • Sleepiness (6-13%)
  • Trouble sleeping (9-12%)
  • Dry mouth (6-9%)
  • Diarrhea (8%)
  • Tiredness (5-8%)

Warnings for Lexapro

  • Worsening depression, suicidal thoughts, and unusual behavior
  • Serotonin syndrome
  • Stopping escitalopram (Lexapro) too suddenly
  • Risk of bleeding
  • Not for use alone in bipolar disorder
  • Glaucoma
  • Life-threatening abnormal heart rhythm (QT prolongation)
  • Low blood sodium levels
  • Sexual problems

Summary for Lyrica

Prescription only

Pregabalin (Lyrica) helps treat nerve pain and fibromyalgia in adults. It can also be taken with other medications to help treat certain seizures in people 1 month and older. Pregabalin (Lyrica) comes as a capsule and oral solution in both brand-name and generic versions. The dosage depends on what condition you're treating, but it's usually taken by mouth 2 or 3 times a day. Common side effects include feeling dizzy and drowsy. This medication is a controlled substance and has interactions, like with alcohol and benzodiazepines.

Indications for Lyrica

Pros and Cons for Lyrica

Pros

  • An option for relieving nerve pain caused by diabetes, shingles, and spinal cord injuries
  • Can take with other anti-seizure medications for partial-onset seizures in people as young as 1 month of age
  • Available in a capsule and liquid

Cons

  • Can cause dizziness and drowsiness
  • Can cause weight gain
  • Is a controlled substance, so there are some rules to follow to get it filled

Common Side Effects for Lyrica

  • Dizziness
  • Drowsiness
  • Headache
  • Weight gain

Warnings for Lyrica

  • Allergic reactions and severe swelling
  • Risk of suicidal thoughts and behavior
  • Higher risk of side effects if you stop taking the medication too suddenly or too fast
  • Slowed breathing
  • Dizziness, sleepiness, and trouble concentrating
  • Swelling of the arms or legs
  • Weight gain
  • Lower platelet levels
  • Possible risk of muscle breakdown

Prices with our coupons for Lexapro vs. Lyrica

Price Card Drug Icon
Escitalopram30 tablets / 10mg
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Pregabalin60 capsules / 75mg
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