Key takeaways
Lexapro (escitalopram) and Cymbalta (duloxetine) are both medications used to treat depression and anxiety, but they belong to different classes. Lexapro is a selective serotonin reuptake inhibitor (SSRI) that works by increasing serotonin levels in the brain, while Cymbalta is a serotonin and norepinephrine reuptake inhibitor (SNRI) that raises both serotonin and norepinephrine levels. Lexapro is also used for generalized anxiety disorder (GAD) and is available in both tablet and liquid forms. Cymbalta, on the other hand, is available as a capsule and treats a wider range of conditions, including diabetic neuropathy, fibromyalgia, and chronic pain. Lexapro can be used in children as young as 12 for depression, whereas Cymbalta can be used for GAD in children as young as 7 and for fibromyalgia in those 13 and older. Both medications can cause side effects like nausea and trouble sleeping, but Cymbalta has additional risks such as liver damage and changes in blood pressure. Lexapro is generally considered a first-choice medication for anxiety and depression, while Cymbalta might be preferred for those with multiple conditions, including chronic pain.
