Key takeaways
Isotretinoin and tretinoin (Retin-A) are both medications derived from vitamin A and belong to the retinoid class. They are used to treat different conditions: isotretinoin is primarily used for severe nodular acne, while tretinoin (Retin-A) is an topical medication used to treat acne in adults and children 12 years and older. Isotretinoin is taken orally twice daily for 4 to 5 months, with dosing based on body weight, and is available in generic forms like Claravis and Amnesteem. Tretinoin (Retin-A) is applied once daily to the skin and is available in generic forms as a cream or gel. Isotretinoin requires the use of two forms of birth control due to the risk of birth defects. Tretinoin (Retin-A) isn't typically recommended for use during pregnancy. Common side effects of isotretinoin include dry skin and lips, while tretinoin (Retin-A) can cause skin irritation, redness, and peeling. Isotretinoin can interact with vitamin A supplements and tetracycline antibiotics. Tretinoin (Retin-A) may cause your acne to get worse at the beginning of treatment, but it should get better as you continue using the medication.
