Key takeaways
Loperamide (Imodium A-D) and bismuth subsalicylate (Pepto-Bismol) are both antidiarrheal medications, but they work differently and have different uses. Loperamide slows down bowel movements and reduces fluid in the intestines, making it effective for controlling diarrhea, including chronic conditions. It is available both over-the-counter and by prescription. Bismuth subsalicylate, on the other hand, treats diarrhea and various stomach issues like nausea, gas, and indigestion by slowing down stomach and intestinal movements and helping reabsorb fluids. It is only available over-the-counter. Loperamide can cause dizziness, drowsiness, and constipation, while bismuth subsalicylate may cause nausea, a bitter taste, and dark-colored stools or tongue. Additionally, bismuth subsalicylate should not be used in children under 12 due to the risk of Reye's syndrome, whereas loperamide can be used in children as young as 2 years old with a prescription. Both medications should not be used for more than two days without consulting a healthcare professional.
