Key takeaways
Ibuprofen (Advil, Motrin) is a nonsteroidal anti-inflammatory drug (NSAID) that treats pain and relieves fevers. Acetaminophen / codeine (Tylenol #3) is also a pain medication, but it’s considered an opioid because it contains codeine. It also contains acetaminophen (Tylenol). Most forms of ibuprofen are available over the counter. It’s usually considered a first-choice medication for mild-to-moderate pain before trying opioids such as Tylenol #3. Common ibuprofen side effects include heartburn and nausea. More seriously, stomach ulcers, bleeding, and kidney damage can occur. It can also raise the risk of a heart attack. Tylenol #3 side effects include drowsiness, constipation, and nausea. Serious risks include misuse, overdose, and liver damage.
