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Humulin R vs. Novolin R

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Humulin R (insulin regular) and Novolin R (insulin regular) are both short-acting insulins used to manage blood sugar levels in people with type 1 and type 2 diabetes. They start working in about 30 minutes and last for several hours. Both medications are available over the counter and can be used with other diabetes medications like metformin. However, Humulin R has a unique, more concentrated form called Humulin R U-500, which is available by prescription only and is meant for those who need large doses of insulin. Novolin R is not available as a concentrated version. Both insulins come in pens and vials, but their storage instructions differ slightly. For example, opened Novolin R vials can be stored at room temperature for up to 42 days, while Humulin R vials can be stored for 31 days. Both medications require careful monitoring of blood sugar levels and proper injection techniques to avoid complications like low blood sugar and infections.

Humulin R

(insulin regular)

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Novolin R

 

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Summary for Humulin R

Prescription or over-the-counter

Humulin R (insulin regular) is a short-acting insulin. It's used to control blood glucose (sugar) levels in adults and children with Type 1 diabetes (T1D) or Type 2 diabetes (T2D). Humulin R (insulin regular) is typically injected under the skin 2 to 3 times daily 30 minutes before meals. Some common side effects of Humulin R (insulin regular) include low blood sugar levels (hypoglycemia) and injection-site redness or pain. Humulin R (insulin regular) is available in two different strengths: U-100 (100 units/mL) and U-500 (500 units/mL). Both strengths come as vials, but the U-500 also comes as a prefilled pen.

Note: Humulin R U-500 is prescription only; Humulin R U-100 is available both OTC and by prescription.

Indications for Humulin R

Pros and Cons for Humulin R

Pros

  • Can help manage both Type 1 and Type 2 diabetes
  • Available over the counter without a prescription (Humulin R U-100 only)
  • Comes as pen and vial (Humulin R U-500 only)

Cons

  • Might cause weight gain
  • Risk of dangerously low blood sugar levels
  • Given as injection

Common Side Effects for Humulin R

  • Low blood sugar
  • Reactions where the medication is injected (e.g., redness, swelling, itching)

Warnings for Humulin R

  • Risk of infections from sharing injection supplies
  • Risk of changes to blood sugar levels with changes to your insulin regimen
  • Dangerously low blood sugar levels (hypoglycemia)
  • Low blood potassium levels
  • Swelling and heart failure
  • Severe allergic reactions

Summary for Novolin R

Prescription or over-the-counter

Novolin R is a short-acting insulin. It's used to control blood glucose (sugar) levels in adults and children with Type 1 or Type 2 diabetes. For the multi-dose vials of Novolin R, you'll need to draw up the dose into a syringe. Single-use prefilled pens called Novolin R FlexPen are also available for easier use. Novolin R is typically injected under the skin 2 to 3 times a day, 30 minutes before a meal. Some common side effects include low blood sugar levels and injection-site redness or pain.

Indications for Novolin R

Pros and Cons for Novolin R

Pros

  • Available over the counter without a prescription
  • Can help manage either Type 1 or Type 2 diabetes
  • Available as a pen and vial

Cons

  • Need multiple injections per day, each time before a meal
  • Can cause weight gain and low blood sugar
  • Must check your blood sugar at home often

Common Side Effects for Novolin R

Warnings for Novolin R

  • Risk of infections from sharing injection supplies
  • Risk of changes to blood sugar levels with changes to your insulin regimen
  • Low blood sugar levels (hypoglycemia)
  • Low potassium levels
  • Swelling and risk of heart failure when using with certain diabetes medications
  • Severe allergic reaction

Prices with our coupons for Humulin R vs. Novolin R

Price Card Drug Icon
Humulin R1 vial / 10ml of 100 units/ml
$50.31$163.53
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Novolin R1 vial / 10ml of 100 units/ml
$52.52$127.41
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