Key takeaways
Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) and Descovy (emtricitabine/tenofovir alafenamide) are both used to treat HIV, but they have some key differences. Genvoya is a combination of four medications, including two NRTIs, an INSTI, and a booster, and is taken once daily with food. Descovy, on the other hand, contains only two NRTIs and can be taken with or without food. Both medications are not available in generic forms. Descovy is also used for HIV prevention (PrEP) except for receptive vaginal sex. Genvoya is a complete regimen for HIV treatment, whereas Descovy must be combined with another medication for full HIV treatment. Both medications can worsen hepatitis B if stopped suddenly and require regular blood tests to monitor kidney health. Common side effects for both include nausea and diarrhea, but Genvoya also lists headache and tiredness more frequently.
