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Evenity vs. Tymlos

Evenity (romosozumab or romosozumab-aqqg) is an injection used to treat osteoporosis (bone loss) in certain women after menopause. These women either have a high risk of fracture or can’t take other medications for bone loss. It's also used when these other medications haven’t worked well enough. Evenity (romosozumab) belongs to the drug class called sclerostin inhibitors. It works to help your bones grow and prevent bone breakdown at the same time. The injection is given once a month by a healthcare professional. Common side effects are joint pain and headache. There's also serious risks of heart attack and stroke. This medication is brand name only; there's no generic available yet.

• Treatment of osteoporosis in certain women after menopause
  • With high risk of fracture
  • Who can’t take other medications for bone loss
  • Who tried other medications for bone loss that didn’t work

• Joint pain (up to 13%)
• Headache (up to 7%)

• Risk of heart attack, stroke, or heart-related death
• Low calcium levels (hypocalcemia)
• Risk of problems in the jawbone (osteonecrosis of the jaw)
• Risk of fractures in the thigh

Tymlos (abaloparatide) is a medication used for osteoporosis in men and postmenopausal women at high risk for breaking bones (fractures). It's given once per day as an injection under the skin. This medication can't be used for longer than 2 years because of a theoretical risk of causing bone cancer.

• Osteoporosis in women who have gone through menopause (postmenopause)
• Osteoporosis in men

• Redness at injection site (up to 58%)
• Swelling at injection site (up to 10%)
• Dizziness (up to 10%)
• Pain at injection site (up to 9%)
• Nausea (up to 8%)

*Percentages of people who reported these side effects might differ between men and postmenopausal women taking this medication.

• Bone cancer
• Sudden low blood pressure (orthostatic hypotension)
• High blood calcium levels
• Kidney stones