Key takeaways
Amphetamine (Evekeo, Evekeo ODT, Adzenys XR ODT, Dyanavel XR) and Vyvanse (lisdexamfetamine) are both stimulant medications used to treat attention deficit-hyperactivity disorder (ADHD). They work by increasing levels of certain chemicals in the brain, such as norepinephrine, dopamine, and serotonin. However, they differ in several ways. Amphetamine is available in various forms, including immediate-release and extended-release tablets, orally disintegrating tablets, and oral liquids, while Vyvanse is available as capsules and chewable tablets. Amphetamine is also approved for narcolepsy and short-term obesity treatment, whereas Vyvanse is approved for moderate-to-severe binge eating disorder (BED) in adults. Vyvanse is typically taken once daily, while amphetamine dosing can vary based on the form and condition being treated. Both medications have a risk of misuse and dependence, potential to cause serious heart problems, and changes in behavior or thoughts. Common side effects for both include difficulty sleeping, loss of appetite, dry mouth and stomach pain. It's important to take these medications exactly as prescribed and discuss any concerns with your healthcare provider.
