Key takeaways
Enalapril (Vasotec) and spironolactone (Aldactone) are both used to treat high blood pressure and heart failure, but they work in different ways and belong to different medication classes. Enalapril is an ACE inhibitor that relaxes blood vessels by blocking a protein called ACE, while spironolactone is a potassium-sparing diuretic that helps your kidneys remove extra water and sodium without lowering potassium levels. Enalapril is typically taken once or twice daily and can cause side effects like tiredness, dizziness, and a dry cough. On the other hand, spironolactone is taken once or a few times a day and can cause side effects such as breast tenderness, lower sex drive, and more frequent urination. Enalapril is not recommended during pregnancy and can cause serious side effects like angioedema and high potassium levels. Spironolactone also has risks, including high potassium levels and abnormal electrolyte levels, and it is not recommended for people with Addison's disease or high potassium levels. Both medications are available in generic forms and require regular blood tests to monitor your health.
